生物相容性
共轭体系
光动力疗法
化学
光敏剂
体内
生物相容性材料
聚合物
材料科学
光化学
活性氧
组合化学
纳米技术
生物物理学
有机化学
生物化学
生物医学工程
医学
生物
生物技术
作者
Taotao Zhou,Rong Hu,Lirong Wang,Yanping Qiu,Guiquan Zhang,Qiyun Deng,Haiyan Zhang,Ping‐An Yin,Bo Situ,Chunlie Zhan,Anjun Qin,Ben Zhong Tang
标识
DOI:10.1002/anie.201916704
摘要
Abstract New, biocompatible materials with favorable antibacterial activity are highly desirable. In this work, we develop a unique conjugated polymer featuring aggregation‐induced emission (AIE) for reliable bacterial eradication. Thanks to the AIE and donor‐π‐acceptor structure, this polymer shows a high reactive oxygen species (ROS)‐generation ability compared to a low‐mass model compound and the common photosensitizer Chlorin E6. Moreover, the selective binding of pathogenic microorganisms over mammalian cells was found, demonstrating its biocompatibility. The effective growth inhibition of bacteria upon polymer treatment under light irradiation was validated in vitro and in vivo. Notably, the recovery from infection after treatment with our polymer is faster than that with cefalotin. Thus, this polymer holds great promise in fighting against bacteria‐related infections in practical applications.
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