Association between HER2 heterogeneity and clinical outcomes of HER2-positive gastric cancer patients treated with trastuzumab

医学 内科学 曲妥珠单抗 免疫组织化学 肿瘤科 队列 胃肠病学 癌症 外科肿瘤学 乳腺癌
作者
Kyunghye Bang,Jaekyung Cheon,Young Soo Park,Hyung‐Don Kim,Min‐Hee Ryu,Yangsoon Park,Meesun Moon,Hyungeun Lee,Yoon‐Koo Kang
出处
期刊:Gastric Cancer [Springer Nature]
卷期号:25 (4): 794-803 被引量:17
标识
DOI:10.1007/s10120-022-01298-6
摘要

The GASTHER1 study showed that re-evaluation of HER2 status rescued 8% of HER2-positive gastric cancer (GC) patients with initially HER2-negative GC. Since rescued HER2 positivity represents HER2 heterogeneity, we aimed to investigate this in a larger cohort with longer follow-up duration.Data of 153 HER2-positive advanced GC patients who received first-line trastuzumab-based chemotherapy were analyzed. Repeat endoscopic biopsy was performed in patients with initially HER2-negative GC. Survival outcomes were analyzed according to the immunohistochemistry (IHC) score (IHC 2+ /in situ hybridization [ISH] + vs IHC 3+), HER2 status (initially vs rescued HER2 positive), and H-score.IHC 2+ /ISH + patients showed worse progression-free survival (PFS) and overall survival (OS) than those with IHC 3+ (p < 0.05). Rescued HER2-positive patients showed worse PFS and OS than initially HER2-positive patients (p < 0.05). Although survival outcomes were comparable according to HER2 status in IHC 2+ /ISH + patients, initially HER2-positive patients showed more favorable PFS and OS than rescued HER2-positive patients (p < 0.05) among those with IHC 3+ . Among the subgroups determined by HER2 status and IHC score, the initially IHC 3+ subgroup had the highest H-score. The low H-score group (H-score ≤ 210) had significantly worse survival outcomes than the high H-score group (H-score > 210) (p < 0.05). An H-score of ≤ 210 was independently associated with shorter OS (HR = 1.54, 95% CI 1.02-2.31, p = 0.04).Rescued HER2-positive patients showed worse clinical outcomes than initially HER2-positive patients, especially those with IHC 3+ . This finding highlights the impact of HER2 heterogeneity, which can be quantified indirectly as an H-score.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
冰凝完成签到,获得积分10
刚刚
Dayton完成签到,获得积分10
刚刚
微笑高山完成签到 ,获得积分10
刚刚
宇宙暴龙战士暴打魔法少女完成签到,获得积分10
1秒前
今后应助luo采纳,获得10
2秒前
张大然完成签到,获得积分20
2秒前
风灵月影应助科研通管家采纳,获得40
3秒前
科研通AI2S应助科研通管家采纳,获得10
3秒前
丰知然应助科研通管家采纳,获得10
3秒前
3秒前
3秒前
3秒前
4秒前
真真真卷不动完成签到,获得积分20
4秒前
orixero应助ifanyz采纳,获得10
4秒前
脑洞疼应助drtianyunhong采纳,获得10
6秒前
逆蝶完成签到,获得积分10
7秒前
8秒前
9秒前
9秒前
云无意发布了新的文献求助10
11秒前
qqq完成签到 ,获得积分10
11秒前
英俊的铭应助天荷采纳,获得10
12秒前
13秒前
mmol发布了新的文献求助10
13秒前
天真幻珊完成签到 ,获得积分10
14秒前
14秒前
川柏树给川柏树的求助进行了留言
14秒前
16秒前
白一丹应助小小罗采纳,获得10
16秒前
大鱼发布了新的文献求助10
16秒前
科研通AI2S应助shenzhou9采纳,获得10
16秒前
medzhou完成签到,获得积分10
16秒前
王佳豪完成签到,获得积分20
18秒前
18秒前
luo发布了新的文献求助10
19秒前
20秒前
reck发布了新的文献求助10
20秒前
耍酷夜阑发布了新的文献求助30
20秒前
mmol完成签到,获得积分10
24秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
2024 Medicinal Chemistry Reviews 400
Dictionary of socialism 350
Mixed-anion Compounds 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3197813
求助须知:如何正确求助?哪些是违规求助? 2846562
关于积分的说明 8059700
捐赠科研通 2511477
什么是DOI,文献DOI怎么找? 1343358
科研通“疑难数据库(出版商)”最低求助积分说明 639537
邀请新用户注册赠送积分活动 609127