Association between HER2 heterogeneity and clinical outcomes of HER2-positive gastric cancer patients treated with trastuzumab

医学 内科学 曲妥珠单抗 免疫组织化学 肿瘤科 队列 胃肠病学 癌症 外科肿瘤学 乳腺癌
作者
Kyunghye Bang,Jaekyung Cheon,Young Soo Park,Hyung‐Don Kim,Min‐Hee Ryu,Yangsoon Park,Meesun Moon,Hyungeun Lee,Yoon‐Koo Kang
出处
期刊:Gastric Cancer [Springer Nature]
卷期号:25 (4): 794-803 被引量:17
标识
DOI:10.1007/s10120-022-01298-6
摘要

The GASTHER1 study showed that re-evaluation of HER2 status rescued 8% of HER2-positive gastric cancer (GC) patients with initially HER2-negative GC. Since rescued HER2 positivity represents HER2 heterogeneity, we aimed to investigate this in a larger cohort with longer follow-up duration.Data of 153 HER2-positive advanced GC patients who received first-line trastuzumab-based chemotherapy were analyzed. Repeat endoscopic biopsy was performed in patients with initially HER2-negative GC. Survival outcomes were analyzed according to the immunohistochemistry (IHC) score (IHC 2+ /in situ hybridization [ISH] + vs IHC 3+), HER2 status (initially vs rescued HER2 positive), and H-score.IHC 2+ /ISH + patients showed worse progression-free survival (PFS) and overall survival (OS) than those with IHC 3+ (p < 0.05). Rescued HER2-positive patients showed worse PFS and OS than initially HER2-positive patients (p < 0.05). Although survival outcomes were comparable according to HER2 status in IHC 2+ /ISH + patients, initially HER2-positive patients showed more favorable PFS and OS than rescued HER2-positive patients (p < 0.05) among those with IHC 3+ . Among the subgroups determined by HER2 status and IHC score, the initially IHC 3+ subgroup had the highest H-score. The low H-score group (H-score ≤ 210) had significantly worse survival outcomes than the high H-score group (H-score > 210) (p < 0.05). An H-score of ≤ 210 was independently associated with shorter OS (HR = 1.54, 95% CI 1.02-2.31, p = 0.04).Rescued HER2-positive patients showed worse clinical outcomes than initially HER2-positive patients, especially those with IHC 3+ . This finding highlights the impact of HER2 heterogeneity, which can be quantified indirectly as an H-score.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
sure完成签到 ,获得积分10
8秒前
9秒前
qh完成签到,获得积分10
10秒前
阔达之桃完成签到,获得积分10
11秒前
11秒前
Guo完成签到 ,获得积分10
12秒前
12秒前
Tysonqu发布了新的文献求助10
13秒前
张豪杰完成签到 ,获得积分10
14秒前
鲸鱼完成签到 ,获得积分10
16秒前
yellow完成签到,获得积分10
18秒前
wBw完成签到,获得积分10
19秒前
xiaofeng5838完成签到,获得积分10
21秒前
巴达天使完成签到,获得积分10
21秒前
阿翼完成签到 ,获得积分10
27秒前
qinqiny完成签到 ,获得积分10
29秒前
yellow关注了科研通微信公众号
32秒前
内向东蒽完成签到 ,获得积分10
32秒前
34秒前
wenhuanwenxian完成签到 ,获得积分10
35秒前
jameslee04完成签到 ,获得积分10
37秒前
Orange应助科研通管家采纳,获得10
39秒前
YD发布了新的文献求助10
39秒前
llhh2024完成签到,获得积分10
39秒前
40秒前
guo完成签到 ,获得积分10
40秒前
飞龙在天完成签到,获得积分0
42秒前
45秒前
瞬间de回眸完成签到 ,获得积分0
49秒前
Yuanyuan发布了新的文献求助10
51秒前
xiaoxiao完成签到 ,获得积分10
53秒前
半颗橙子完成签到 ,获得积分10
53秒前
YD完成签到,获得积分10
58秒前
Owen应助Yuanyuan采纳,获得10
1分钟前
1分钟前
1分钟前
沉默傲芙完成签到 ,获得积分10
1分钟前
1分钟前
Murphy完成签到,获得积分10
1分钟前
wusj120发布了新的文献求助10
1分钟前
高分求助中
Evolution 3rd edition 1500
保险藏宝图 1000
Lire en communiste 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3183763
求助须知:如何正确求助?哪些是违规求助? 2833823
关于积分的说明 7995626
捐赠科研通 2496089
什么是DOI,文献DOI怎么找? 1331890
科研通“疑难数据库(出版商)”最低求助积分说明 636455
邀请新用户注册赠送积分活动 603625