Association between HER2 heterogeneity and clinical outcomes of HER2-positive gastric cancer patients treated with trastuzumab

医学 内科学 曲妥珠单抗 免疫组织化学 肿瘤科 队列 胃肠病学 癌症 外科肿瘤学 乳腺癌
作者
Kyunghye Bang,Jaekyung Cheon,Young Soo Park,Hyung‐Don Kim,Min‐Hee Ryu,Yangsoon Park,Meesun Moon,Hyungeun Lee,Yoon‐Koo Kang
出处
期刊:Gastric Cancer [Springer Nature]
卷期号:25 (4): 794-803 被引量:17
标识
DOI:10.1007/s10120-022-01298-6
摘要

The GASTHER1 study showed that re-evaluation of HER2 status rescued 8% of HER2-positive gastric cancer (GC) patients with initially HER2-negative GC. Since rescued HER2 positivity represents HER2 heterogeneity, we aimed to investigate this in a larger cohort with longer follow-up duration.Data of 153 HER2-positive advanced GC patients who received first-line trastuzumab-based chemotherapy were analyzed. Repeat endoscopic biopsy was performed in patients with initially HER2-negative GC. Survival outcomes were analyzed according to the immunohistochemistry (IHC) score (IHC 2+ /in situ hybridization [ISH] + vs IHC 3+), HER2 status (initially vs rescued HER2 positive), and H-score.IHC 2+ /ISH + patients showed worse progression-free survival (PFS) and overall survival (OS) than those with IHC 3+ (p < 0.05). Rescued HER2-positive patients showed worse PFS and OS than initially HER2-positive patients (p < 0.05). Although survival outcomes were comparable according to HER2 status in IHC 2+ /ISH + patients, initially HER2-positive patients showed more favorable PFS and OS than rescued HER2-positive patients (p < 0.05) among those with IHC 3+ . Among the subgroups determined by HER2 status and IHC score, the initially IHC 3+ subgroup had the highest H-score. The low H-score group (H-score ≤ 210) had significantly worse survival outcomes than the high H-score group (H-score > 210) (p < 0.05). An H-score of ≤ 210 was independently associated with shorter OS (HR = 1.54, 95% CI 1.02-2.31, p = 0.04).Rescued HER2-positive patients showed worse clinical outcomes than initially HER2-positive patients, especially those with IHC 3+ . This finding highlights the impact of HER2 heterogeneity, which can be quantified indirectly as an H-score.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
小树发布了新的文献求助10
刚刚
幽默的小之完成签到,获得积分10
刚刚
情怀应助冷艳的孤晴采纳,获得10
1秒前
洁净灭男发布了新的文献求助10
1秒前
2秒前
yao发布了新的文献求助10
2秒前
anna完成签到,获得积分10
5秒前
6秒前
6秒前
丰知然应助yizhizhu采纳,获得10
11秒前
12秒前
Skymi发布了新的文献求助10
12秒前
orixero应助fifteen采纳,获得10
12秒前
real完成签到 ,获得积分10
13秒前
1234完成签到,获得积分10
13秒前
14秒前
Joshua发布了新的文献求助10
15秒前
肥陈完成签到,获得积分10
16秒前
Jayden完成签到 ,获得积分10
17秒前
dlut0407完成签到,获得积分10
18秒前
Skymi完成签到,获得积分10
19秒前
阿默发布了新的文献求助10
19秒前
yao完成签到,获得积分10
21秒前
liu完成签到,获得积分10
23秒前
沉默的谷秋完成签到,获得积分10
25秒前
26秒前
27秒前
matt发布了新的文献求助10
30秒前
善学以致用应助Bressanone采纳,获得10
30秒前
yanghua完成签到,获得积分10
33秒前
Joshua完成签到,获得积分10
36秒前
喔喔完成签到,获得积分10
38秒前
科目三应助幽默的小之采纳,获得10
39秒前
Ava应助Ray采纳,获得10
39秒前
忧郁的南瓜完成签到,获得积分10
42秒前
不配.应助shain采纳,获得10
43秒前
meta发布了新的文献求助10
45秒前
Fiona完成签到 ,获得积分10
46秒前
善学以致用应助木cheng采纳,获得10
49秒前
栗子应助激狂大地万里冰采纳,获得10
55秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Evolution 3rd edition 1500
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
Handbook on People's China (1957) 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3188844
求助须知:如何正确求助?哪些是违规求助? 2838291
关于积分的说明 8019358
捐赠科研通 2501127
什么是DOI,文献DOI怎么找? 1335327
科研通“疑难数据库(出版商)”最低求助积分说明 637495
邀请新用户注册赠送积分活动 605618