Association between HER2 heterogeneity and clinical outcomes of HER2-positive gastric cancer patients treated with trastuzumab

医学 内科学 曲妥珠单抗 免疫组织化学 肿瘤科 队列 胃肠病学 癌症 外科肿瘤学 乳腺癌
作者
Kyunghye Bang,Jaekyung Cheon,Young Soo Park,Hyung‐Don Kim,Min‐Hee Ryu,Yangsoon Park,Meesun Moon,Hyungeun Lee,Yoon‐Koo Kang
出处
期刊:Gastric Cancer [Springer Nature]
卷期号:25 (4): 794-803 被引量:17
标识
DOI:10.1007/s10120-022-01298-6
摘要

The GASTHER1 study showed that re-evaluation of HER2 status rescued 8% of HER2-positive gastric cancer (GC) patients with initially HER2-negative GC. Since rescued HER2 positivity represents HER2 heterogeneity, we aimed to investigate this in a larger cohort with longer follow-up duration.Data of 153 HER2-positive advanced GC patients who received first-line trastuzumab-based chemotherapy were analyzed. Repeat endoscopic biopsy was performed in patients with initially HER2-negative GC. Survival outcomes were analyzed according to the immunohistochemistry (IHC) score (IHC 2+ /in situ hybridization [ISH] + vs IHC 3+), HER2 status (initially vs rescued HER2 positive), and H-score.IHC 2+ /ISH + patients showed worse progression-free survival (PFS) and overall survival (OS) than those with IHC 3+ (p < 0.05). Rescued HER2-positive patients showed worse PFS and OS than initially HER2-positive patients (p < 0.05). Although survival outcomes were comparable according to HER2 status in IHC 2+ /ISH + patients, initially HER2-positive patients showed more favorable PFS and OS than rescued HER2-positive patients (p < 0.05) among those with IHC 3+ . Among the subgroups determined by HER2 status and IHC score, the initially IHC 3+ subgroup had the highest H-score. The low H-score group (H-score ≤ 210) had significantly worse survival outcomes than the high H-score group (H-score > 210) (p < 0.05). An H-score of ≤ 210 was independently associated with shorter OS (HR = 1.54, 95% CI 1.02-2.31, p = 0.04).Rescued HER2-positive patients showed worse clinical outcomes than initially HER2-positive patients, especially those with IHC 3+ . This finding highlights the impact of HER2 heterogeneity, which can be quantified indirectly as an H-score.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
1秒前
3秒前
俏皮的绝山完成签到,获得积分20
4秒前
4秒前
4秒前
酷波er应助AJima采纳,获得10
5秒前
5秒前
不配.应助怡然问晴采纳,获得10
6秒前
机器爱好者关注了科研通微信公众号
6秒前
科研搬运工完成签到,获得积分10
6秒前
善学以致用应助HOPKINSON采纳,获得10
7秒前
apple发布了新的文献求助10
7秒前
无花果应助lifeng采纳,获得10
8秒前
纳古菌完成签到,获得积分10
8秒前
yang3023008发布了新的文献求助10
8秒前
粥粥发布了新的文献求助10
9秒前
坚定涵柏发布了新的文献求助10
9秒前
帅气的Q发布了新的文献求助30
9秒前
9秒前
10秒前
英姑应助J11采纳,获得10
10秒前
11秒前
12秒前
丝丝完成签到,获得积分10
12秒前
12秒前
FashionBoy应助风笛采纳,获得10
13秒前
张杰发布了新的文献求助10
13秒前
ququ发布了新的文献求助10
14秒前
科目三应助牧楊人采纳,获得10
14秒前
14秒前
英姑应助皮皮狗采纳,获得10
15秒前
16秒前
16秒前
飘逸问晴发布了新的文献求助20
17秒前
木习发布了新的文献求助10
17秒前
爆米花应助帅气的Q采纳,获得10
17秒前
dtf完成签到,获得积分10
17秒前
粥粥完成签到,获得积分10
17秒前
lucas发布了新的文献求助10
17秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
2024 Medicinal Chemistry Reviews 400
Dictionary of socialism 350
Geochemistry, 2nd Edition 地球化学经典教科书第二版 300
Idoxuridine 260
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3193893
求助须知:如何正确求助?哪些是违规求助? 2842876
关于积分的说明 8041623
捐赠科研通 2507145
什么是DOI,文献DOI怎么找? 1339715
科研通“疑难数据库(出版商)”最低求助积分说明 638777
邀请新用户注册赠送积分活动 607628