已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Enabling precision monitoring of psoriasis treatment by optoacoustic mesoscopy

医学 精密医学 银屑病 背景(考古学) 个性化医疗 人口 皮肤病科 病理 生物信息学 生物 环境卫生 古生物学
作者
Benedikt Hindelang,T. Nau,Ludwig Englert,Andrei Berezhnoi,Felix Lauffer,Ulf Darsow,Tilo Biedermann,Kilian Eyerich,Juan Aguirre,Vasilis Ntziachristos
出处
期刊:Science Translational Medicine [American Association for the Advancement of Science (AAAS)]
卷期号:14 (644) 被引量:22
标识
DOI:10.1126/scitranslmed.abm8059
摘要

Psoriasis is a widespread inflammatory skin disease affecting about 2% of the general population. Recently, treatments that specifically target key proinflammatory cytokines driving the disease have been developed to complement conventional therapies with unspecific antiproliferative or anti-inflammatory effects. Efficient monitoring of treatment efficacy in the context of precision medicine and the assessment of new therapeutics require accurate noninvasive readouts of disease progression. However, characterization of psoriasis treatment remains subjective based on visual and palpatory clinical assessment of features observed on the skin surface. We hypothesized that optoacoustic (photoacoustic) mesoscopy could offer label-free assessment of inflammation biomarkers, extracted from three-dimensional (3D) high-resolution images of the human skin, not attainable by other noninvasive methods. We developed a second-generation ultra-broadband optoacoustic mesoscopy system, featuring sub–10-μm resolution and advanced motion correction technology, and performed 80 longitudinal measurements of 20 psoriatic skin plaques in humans under conventional inpatient treatment or receiving biologics with concomitant topical corticosteroid treatment. Optoacoustic image analysis revealed inflammatory and morphological skin features that indicated treatment efficacy with sensitivity, accuracy, and precision that was not possible using clinical metrics. We identify 3D imaging biomarkers that reveal responses to treatment and offer the potential to facilitate disease and treatment characterization. Our findings suggest that optoacoustic mesoscopy may offer a method of choice for yielding both qualitative and quantitative evaluations of skin treatments that are inaccessible by other methods, potentially enabling optimized therapies and precision medicine in dermatology.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
FCL完成签到,获得积分10
刚刚
2秒前
烟花应助HelenZ采纳,获得10
3秒前
不学习的牛蛙完成签到 ,获得积分10
5秒前
璐洋发布了新的文献求助10
5秒前
6秒前
lixuebin完成签到 ,获得积分10
6秒前
6秒前
maction应助科研通管家采纳,获得20
10秒前
李爱国应助科研通管家采纳,获得10
10秒前
HELAOBAN完成签到,获得积分20
11秒前
lixia完成签到 ,获得积分10
11秒前
郜雨寒发布了新的文献求助10
12秒前
追寻夏烟完成签到 ,获得积分10
13秒前
17秒前
璐洋完成签到,获得积分10
18秒前
尚寻完成签到,获得积分10
18秒前
HelenZ发布了新的文献求助10
22秒前
myg123完成签到 ,获得积分10
23秒前
23秒前
冰西瓜完成签到 ,获得积分10
25秒前
小苔藓完成签到 ,获得积分10
29秒前
HELAOBAN发布了新的文献求助10
29秒前
Ava应助兴奋的白桃采纳,获得10
29秒前
科研通AI2S应助思明采纳,获得10
33秒前
一点完成签到 ,获得积分10
33秒前
小宝完成签到,获得积分10
39秒前
神勇的向薇完成签到 ,获得积分10
41秒前
咿咿呀呀完成签到,获得积分10
42秒前
45秒前
45秒前
周青春偶像完成签到 ,获得积分10
46秒前
小花小宝和阿飞完成签到 ,获得积分10
49秒前
50秒前
51秒前
聪仔完成签到,获得积分20
51秒前
hzy发布了新的文献求助10
53秒前
酷波er应助鲤鱼书双采纳,获得30
1分钟前
光亮如彤完成签到,获得积分10
1分钟前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
Dictionary of socialism 350
Mixed-anion Compounds 300
Geochemistry, 2nd Edition 地球化学经典教科书第二版 300
Idoxuridine 260
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3196586
求助须知:如何正确求助?哪些是违规求助? 2845284
关于积分的说明 8053900
捐赠科研通 2509924
什么是DOI,文献DOI怎么找? 1342121
科研通“疑难数据库(出版商)”最低求助积分说明 639320
邀请新用户注册赠送积分活动 608608