Enabling precision monitoring of psoriasis treatment by optoacoustic mesoscopy

医学 精密医学 银屑病 背景(考古学) 个性化医疗 人口 皮肤病科 病理 生物信息学 生物 环境卫生 古生物学
作者
Benedikt Hindelang,T. Nau,Ludwig Englert,Andrei Berezhnoi,Felix Lauffer,Ulf Darsow,Tilo Biedermann,Kilian Eyerich,Juan Aguirre,Vasilis Ntziachristos
出处
期刊:Science Translational Medicine [American Association for the Advancement of Science (AAAS)]
卷期号:14 (644) 被引量:22
标识
DOI:10.1126/scitranslmed.abm8059
摘要

Psoriasis is a widespread inflammatory skin disease affecting about 2% of the general population. Recently, treatments that specifically target key proinflammatory cytokines driving the disease have been developed to complement conventional therapies with unspecific antiproliferative or anti-inflammatory effects. Efficient monitoring of treatment efficacy in the context of precision medicine and the assessment of new therapeutics require accurate noninvasive readouts of disease progression. However, characterization of psoriasis treatment remains subjective based on visual and palpatory clinical assessment of features observed on the skin surface. We hypothesized that optoacoustic (photoacoustic) mesoscopy could offer label-free assessment of inflammation biomarkers, extracted from three-dimensional (3D) high-resolution images of the human skin, not attainable by other noninvasive methods. We developed a second-generation ultra-broadband optoacoustic mesoscopy system, featuring sub–10-μm resolution and advanced motion correction technology, and performed 80 longitudinal measurements of 20 psoriatic skin plaques in humans under conventional inpatient treatment or receiving biologics with concomitant topical corticosteroid treatment. Optoacoustic image analysis revealed inflammatory and morphological skin features that indicated treatment efficacy with sensitivity, accuracy, and precision that was not possible using clinical metrics. We identify 3D imaging biomarkers that reveal responses to treatment and offer the potential to facilitate disease and treatment characterization. Our findings suggest that optoacoustic mesoscopy may offer a method of choice for yielding both qualitative and quantitative evaluations of skin treatments that are inaccessible by other methods, potentially enabling optimized therapies and precision medicine in dermatology.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
789完成签到,获得积分10
1秒前
SuperJunior发布了新的文献求助10
1秒前
大魔王完成签到,获得积分10
2秒前
慕青应助王金金采纳,获得10
2秒前
吃的发布了新的文献求助200
2秒前
2秒前
晴心完成签到,获得积分10
5秒前
789发布了新的文献求助10
6秒前
贝利亚完成签到,获得积分10
7秒前
雾见春完成签到 ,获得积分10
7秒前
852应助赫尔坤兰采纳,获得10
8秒前
9秒前
科研通AI2S应助现代的妍采纳,获得10
9秒前
11秒前
铅笔刀完成签到,获得积分10
13秒前
13秒前
haoxin完成签到,获得积分10
14秒前
16秒前
17秒前
科研通AI2S应助快乐的萝莉采纳,获得10
18秒前
NZH驳回了充电宝应助
19秒前
阿星应助小猪熊采纳,获得10
19秒前
激昂的幻梦完成签到,获得积分10
21秒前
英姑应助lichy采纳,获得10
21秒前
21秒前
22秒前
科目三应助carbon-dots采纳,获得10
23秒前
cynthiaLLL完成签到 ,获得积分10
23秒前
碳烤小黑茶完成签到 ,获得积分10
24秒前
24秒前
上官若男应助尼克拉倒采纳,获得10
25秒前
25秒前
高高秋发布了新的文献求助10
25秒前
佳期如梦发布了新的文献求助20
26秒前
27秒前
28秒前
passengerrrrr发布了新的文献求助10
29秒前
无心的蓝完成签到 ,获得积分10
29秒前
欢呼的向秋完成签到 ,获得积分10
29秒前
柚又完成签到 ,获得积分10
29秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Evolution 3rd edition 1500
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3187181
求助须知:如何正确求助?哪些是违规求助? 2837087
关于积分的说明 8013241
捐赠科研通 2499689
什么是DOI,文献DOI怎么找? 1334515
科研通“疑难数据库(出版商)”最低求助积分说明 637194
邀请新用户注册赠送积分活动 605102