已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Enabling precision monitoring of psoriasis treatment by optoacoustic mesoscopy

医学 精密医学 银屑病 背景(考古学) 个性化医疗 人口 皮肤病科 病理 生物信息学 生物 环境卫生 古生物学
作者
Benedikt Hindelang,T. Nau,Ludwig Englert,Andrei Berezhnoi,Felix Lauffer,Ulf Darsow,Tilo Biedermann,Kilian Eyerich,Juan Aguirre,Vasilis Ntziachristos
出处
期刊:Science Translational Medicine [American Association for the Advancement of Science (AAAS)]
卷期号:14 (644) 被引量:22
标识
DOI:10.1126/scitranslmed.abm8059
摘要

Psoriasis is a widespread inflammatory skin disease affecting about 2% of the general population. Recently, treatments that specifically target key proinflammatory cytokines driving the disease have been developed to complement conventional therapies with unspecific antiproliferative or anti-inflammatory effects. Efficient monitoring of treatment efficacy in the context of precision medicine and the assessment of new therapeutics require accurate noninvasive readouts of disease progression. However, characterization of psoriasis treatment remains subjective based on visual and palpatory clinical assessment of features observed on the skin surface. We hypothesized that optoacoustic (photoacoustic) mesoscopy could offer label-free assessment of inflammation biomarkers, extracted from three-dimensional (3D) high-resolution images of the human skin, not attainable by other noninvasive methods. We developed a second-generation ultra-broadband optoacoustic mesoscopy system, featuring sub–10-μm resolution and advanced motion correction technology, and performed 80 longitudinal measurements of 20 psoriatic skin plaques in humans under conventional inpatient treatment or receiving biologics with concomitant topical corticosteroid treatment. Optoacoustic image analysis revealed inflammatory and morphological skin features that indicated treatment efficacy with sensitivity, accuracy, and precision that was not possible using clinical metrics. We identify 3D imaging biomarkers that reveal responses to treatment and offer the potential to facilitate disease and treatment characterization. Our findings suggest that optoacoustic mesoscopy may offer a method of choice for yielding both qualitative and quantitative evaluations of skin treatments that are inaccessible by other methods, potentially enabling optimized therapies and precision medicine in dermatology.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
完美世界应助XSDXXZ采纳,获得10
1秒前
隐形曼青应助eth采纳,获得10
2秒前
杨欣1994完成签到,获得积分20
3秒前
科研通AI2S应助BruceKKKK采纳,获得10
3秒前
3秒前
4秒前
花花发布了新的文献求助10
4秒前
5秒前
holi完成签到 ,获得积分10
6秒前
风声鹤立发布了新的文献求助10
8秒前
zzz发布了新的文献求助10
8秒前
9秒前
调研昵称发布了新的文献求助10
9秒前
汉堡包应助mmm采纳,获得10
9秒前
杨欣1994发布了新的文献求助10
9秒前
斯文败类应助瑞雪采纳,获得10
9秒前
modesty完成签到,获得积分20
9秒前
夏凛完成签到 ,获得积分10
10秒前
鹤见知完成签到,获得积分10
11秒前
12秒前
13秒前
lulu完成签到,获得积分10
13秒前
JamesPei应助yhx采纳,获得10
14秒前
15秒前
喜悦兔子完成签到 ,获得积分10
16秒前
科研通AI2S应助modesty采纳,获得10
16秒前
小周同学发布了新的文献求助10
16秒前
17秒前
17秒前
领导范儿应助蔚蓝天空采纳,获得10
17秒前
cx发布了新的文献求助10
18秒前
20秒前
jl发布了新的文献求助20
21秒前
科研通AI2S应助something采纳,获得10
22秒前
wjr发布了新的文献求助10
22秒前
碳正离子发布了新的文献求助10
23秒前
kem发布了新的文献求助20
24秒前
26秒前
27秒前
Su完成签到,获得积分10
28秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
India's foreign trade policy and its performance in the world economy 450
Structural Inorganic Chemistry 400
Dictionary of socialism 350
Mixed-anion Compounds 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3196352
求助须知:如何正确求助?哪些是违规求助? 2845157
关于积分的说明 8053048
捐赠科研通 2509764
什么是DOI,文献DOI怎么找? 1341970
科研通“疑难数据库(出版商)”最低求助积分说明 639304
邀请新用户注册赠送积分活动 608563