Enabling precision monitoring of psoriasis treatment by optoacoustic mesoscopy

医学 精密医学 银屑病 背景(考古学) 个性化医疗 人口 皮肤病科 病理 生物信息学 生物 环境卫生 古生物学
作者
Benedikt Hindelang,T. Nau,Ludwig Englert,Andrei Berezhnoi,Felix Lauffer,Ulf Darsow,Tilo Biedermann,Kilian Eyerich,Juan Aguirre,Vasilis Ntziachristos
出处
期刊:Science Translational Medicine [American Association for the Advancement of Science (AAAS)]
卷期号:14 (644) 被引量:22
标识
DOI:10.1126/scitranslmed.abm8059
摘要

Psoriasis is a widespread inflammatory skin disease affecting about 2% of the general population. Recently, treatments that specifically target key proinflammatory cytokines driving the disease have been developed to complement conventional therapies with unspecific antiproliferative or anti-inflammatory effects. Efficient monitoring of treatment efficacy in the context of precision medicine and the assessment of new therapeutics require accurate noninvasive readouts of disease progression. However, characterization of psoriasis treatment remains subjective based on visual and palpatory clinical assessment of features observed on the skin surface. We hypothesized that optoacoustic (photoacoustic) mesoscopy could offer label-free assessment of inflammation biomarkers, extracted from three-dimensional (3D) high-resolution images of the human skin, not attainable by other noninvasive methods. We developed a second-generation ultra-broadband optoacoustic mesoscopy system, featuring sub–10-μm resolution and advanced motion correction technology, and performed 80 longitudinal measurements of 20 psoriatic skin plaques in humans under conventional inpatient treatment or receiving biologics with concomitant topical corticosteroid treatment. Optoacoustic image analysis revealed inflammatory and morphological skin features that indicated treatment efficacy with sensitivity, accuracy, and precision that was not possible using clinical metrics. We identify 3D imaging biomarkers that reveal responses to treatment and offer the potential to facilitate disease and treatment characterization. Our findings suggest that optoacoustic mesoscopy may offer a method of choice for yielding both qualitative and quantitative evaluations of skin treatments that are inaccessible by other methods, potentially enabling optimized therapies and precision medicine in dermatology.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
nicolaslcq完成签到,获得积分10
1秒前
2秒前
张苗苗发布了新的文献求助10
2秒前
醉熏的伊完成签到,获得积分10
3秒前
李萌萌完成签到 ,获得积分10
3秒前
serene完成签到,获得积分10
4秒前
Zhouzhou完成签到,获得积分10
4秒前
翟函完成签到,获得积分10
4秒前
所所应助hbc采纳,获得10
4秒前
充电宝应助科研通管家采纳,获得10
5秒前
5秒前
5秒前
5秒前
5秒前
传奇3应助科研通管家采纳,获得10
5秒前
Billy应助Moon采纳,获得30
6秒前
6秒前
琳琳完成签到,获得积分10
6秒前
6秒前
宇宙无敌霸王龙战士一号完成签到,获得积分10
7秒前
8秒前
8秒前
8秒前
一个橡果完成签到,获得积分10
9秒前
朝气发布了新的文献求助10
9秒前
11秒前
11秒前
哥哥发布了新的文献求助10
11秒前
12秒前
迷人的冥完成签到,获得积分10
12秒前
李a发布了新的文献求助10
12秒前
搜集达人应助Yhcir采纳,获得10
12秒前
FartKing完成签到,获得积分10
12秒前
badada发布了新的文献求助10
13秒前
丹曦完成签到,获得积分10
14秒前
过冷风发布了新的文献求助30
14秒前
sssss发布了新的文献求助10
15秒前
15秒前
FartKing发布了新的文献求助10
15秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
2024 Medicinal Chemistry Reviews 400
Dictionary of socialism 350
Geochemistry, 2nd Edition 地球化学经典教科书第二版 300
Idoxuridine 260
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3193941
求助须知:如何正确求助?哪些是违规求助? 2842889
关于积分的说明 8041988
捐赠科研通 2507215
什么是DOI,文献DOI怎么找? 1339760
科研通“疑难数据库(出版商)”最低求助积分说明 638798
邀请新用户注册赠送积分活动 607628