亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Enabling precision monitoring of psoriasis treatment by optoacoustic mesoscopy

医学 精密医学 银屑病 背景(考古学) 个性化医疗 人口 皮肤病科 病理 生物信息学 生物 环境卫生 古生物学
作者
Benedikt Hindelang,T. Nau,Ludwig Englert,Andrei Berezhnoi,Felix Lauffer,Ulf Darsow,Tilo Biedermann,Kilian Eyerich,Juan Aguirre,Vasilis Ntziachristos
出处
期刊:Science Translational Medicine [American Association for the Advancement of Science (AAAS)]
卷期号:14 (644) 被引量:22
标识
DOI:10.1126/scitranslmed.abm8059
摘要

Psoriasis is a widespread inflammatory skin disease affecting about 2% of the general population. Recently, treatments that specifically target key proinflammatory cytokines driving the disease have been developed to complement conventional therapies with unspecific antiproliferative or anti-inflammatory effects. Efficient monitoring of treatment efficacy in the context of precision medicine and the assessment of new therapeutics require accurate noninvasive readouts of disease progression. However, characterization of psoriasis treatment remains subjective based on visual and palpatory clinical assessment of features observed on the skin surface. We hypothesized that optoacoustic (photoacoustic) mesoscopy could offer label-free assessment of inflammation biomarkers, extracted from three-dimensional (3D) high-resolution images of the human skin, not attainable by other noninvasive methods. We developed a second-generation ultra-broadband optoacoustic mesoscopy system, featuring sub–10-μm resolution and advanced motion correction technology, and performed 80 longitudinal measurements of 20 psoriatic skin plaques in humans under conventional inpatient treatment or receiving biologics with concomitant topical corticosteroid treatment. Optoacoustic image analysis revealed inflammatory and morphological skin features that indicated treatment efficacy with sensitivity, accuracy, and precision that was not possible using clinical metrics. We identify 3D imaging biomarkers that reveal responses to treatment and offer the potential to facilitate disease and treatment characterization. Our findings suggest that optoacoustic mesoscopy may offer a method of choice for yielding both qualitative and quantitative evaluations of skin treatments that are inaccessible by other methods, potentially enabling optimized therapies and precision medicine in dermatology.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Ava应助牧百川采纳,获得30
10秒前
11秒前
zai完成签到 ,获得积分10
11秒前
欧皇发布了新的文献求助10
18秒前
26秒前
27秒前
张爱学发布了新的文献求助10
33秒前
脆皮鱼完成签到 ,获得积分10
34秒前
欧皇发布了新的文献求助10
40秒前
科研通AI2S应助张爱学采纳,获得10
54秒前
SciGPT应助任无施采纳,获得50
58秒前
科研通AI2S应助科研通管家采纳,获得10
1分钟前
Billy应助科研通管家采纳,获得10
1分钟前
张爱学完成签到,获得积分10
1分钟前
欧皇完成签到,获得积分20
1分钟前
Leo完成签到 ,获得积分10
1分钟前
jyy完成签到,获得积分10
1分钟前
Lucas应助ikki采纳,获得10
1分钟前
头孢克肟完成签到 ,获得积分10
1分钟前
CodeCraft应助steleegee采纳,获得10
1分钟前
1分钟前
CodeCraft应助好好采纳,获得10
1分钟前
yuan完成签到 ,获得积分10
1分钟前
韦老虎完成签到,获得积分10
2分钟前
2分钟前
任无施完成签到,获得积分10
2分钟前
任无施发布了新的文献求助50
2分钟前
2分钟前
好好发布了新的文献求助10
2分钟前
Billy应助科研通管家采纳,获得10
3分钟前
3分钟前
连长完成签到,获得积分10
3分钟前
3分钟前
牧百川发布了新的文献求助30
3分钟前
无花果应助好好采纳,获得10
3分钟前
好好完成签到,获得积分10
3分钟前
小王完成签到 ,获得积分10
3分钟前
4分钟前
完美世界应助geye采纳,获得10
4分钟前
呼延水云发布了新的文献求助10
4分钟前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
A real-time energy management strategy based on fuzzy control and ECMS for PHEVs 400
Handbook on People's China (1957) 400
2024 Medicinal Chemistry Reviews 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3189990
求助须知:如何正确求助?哪些是违规求助? 2839207
关于积分的说明 8023318
捐赠科研通 2502108
什么是DOI,文献DOI怎么找? 1336300
科研通“疑难数据库(出版商)”最低求助积分说明 637818
邀请新用户注册赠送积分活动 605919