超分子化学
葡萄糖氧化酶
超分子聚合物
超分子组装
材料科学
纳米技术
组合化学
级联反应
聚合
化学
催化作用
聚合物
有机化学
生物传感器
分子
作者
Hailiang Zhang,Yong Chen,Rong Zhang,Qilin Yu,Yong Liu,Yu Liu
出处
期刊:ACS Nano
[American Chemical Society]
日期:2022-06-13
卷期号:16 (6): 9929-9937
被引量:42
标识
DOI:10.1021/acsnano.2c04566
摘要
Supramolecular nanofunctional materials have attracted increasing attention from scientific researchers due to their advantages in biomedicine. Herein, we construct a nanosupramolecular cascade reactor through the cooperative interaction of multiple noncovalent bonds, which include chitosan, sulfobutylether-β-cyclodextrin, ferrous ions, and glucose oxidase. Under the activation of glucose, hydroxyl radicals generated from the nanoconfinement supramolecular cascade reaction process are able to initiate the radical polymerization process of vinyl monomers to form hydrogel network structures while inhibiting resistant bacterial infection. The results of the diabetic wound experiment confirmed the capacity of the glucose-activated nanoconfinement supramolecular cascade reaction in situ for potent antimicrobial efficacy and wound protection. This strategy of "two birds with one stone" provides a convenient method for the application of supramolecular nanomaterial in the field of biomedicine.
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