精神病
帕金森病
内科学
萧条(经济学)
疾病
队列
医学
生物标志物
精神科
焦虑
心理学
生物化学
化学
经济
宏观经济学
作者
Lucy L. Gibson,Thomas Pollak,Amanda Heslegrave,Abdul Hye,Lucia Batzu,Silvia Rota,Dhaval Trivedi,Timothy Nicholson,Dominic ffytche,Henrik Zetterberg,К. Ray Chaudhuri,Dag Aarsland
出处
期刊:Journal of Parkinson's disease
[IOS Press]
日期:2022-07-08
卷期号:12 (5): 1527-1538
被引量:2
摘要
Background: Neuropsychiatric symptoms are common and important to people with Parkinson’s disease (PD), but their etiology is poorly understood. Plasma neurofilament light (NfL) and p-tau181 are biomarkers of neuro-axonal degeneration and tau pathology respectively, which have yet to be explored in association with the affective and psychotic symptoms in PD. Objective: To investigate the relationship between plasma NfL and p-tau181 with the affective and psychotic symptoms in PD. Methods: We assessed the baseline concentration of plasma NfL and p-tau181 in a cohort of 108 patients with PD and 38 healthy controls. A subgroup of patients (n = 63) were assessed annually with clinical measures for up to 7 years. Psychotic symptoms were assessed using the Non-Motor Symptom Scale and affective symptoms were measured in the Hospital Anxiety and Depression Scale. Results: Baseline plasma NfL was a significant predictor of psychotic symptoms longitudinally across the study adjusted for age, Hoehn and Yahr stage, duration of follow up, duration of disease, baseline levodopa and dopamine agonist medication, and baseline cognition: (OR 8.15 [95% CI 1.40–47.4], p = 0.020). There was no association between NfL concentration and the cumulative prevalence of affective symptoms. Plasma p-tau181 concentration was not associated with psychotic or affective symptoms. Conclusion: These findings suggest psychotic symptoms are associated with greater neurodegeneration in PD. Further studies are needed to explore NfL as a potential biomarker for psychosis in PD.
科研通智能强力驱动
Strongly Powered by AbleSci AI