1,2,3-Triazole Derivatives with Anti-breast Cancer Potential

Abstract: Breast cancer is one of the most prevalent malignant diseases, and one of the main causes of mortality among women across the world. Despite advances in chemotherapy, drug resistance remains a major clinical concern, creating an urgent need to explore novel anti-breast cancer drugs. 1,2,3-triazole is a privileged moiety, and its derivatives could inhibit cancer cell proliferation and induce cell cycle arrest and apoptosis. Accordingly, 1,2,3-triazole derivatives possess profound ac-tivity against various cancers, including breast cancer. This review summarizes the latest progress related to the anti-breast cancer potential of 1,2,3-triazole derivatives, covering articles published from January 2017 to December 2021. The mechanisms of action and structure-activity relation-ships (SARs) are also discussed for the further rational design of more effective candidates.