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Preparation of antibacterial polypeptides with different topologies and their antibacterial properties

生物相容性 化学 抗菌活性 树枝状大分子 抗菌剂 最低杀菌浓度 嫁接 组合化学 抗菌肽 抗生素 细菌 纳米技术 最小抑制浓度 材料科学 有机化学 生物化学 生物 聚合物 遗传学
作者
Xiaodan Wang,Fei Yang,Huawei Yang,Xu Zhang,Haoyu Tang,Shifang Luan
出处
期刊:Biomaterials Science [The Royal Society of Chemistry]
卷期号:10 (3): 834-845 被引量:12
标识
DOI:10.1039/d1bm01620b
摘要

Antimicrobial peptides (AMPs) are attractive antimicrobial agents used to combat bacterial infections, and have been advanced to be one of the most promising alternatives to conventional antibiotics. They stand out for their attractive broad-spectrum activity, unmatched antibacterial mechanism that is not prone to develop drug resistance and diversified topologies, which can be fabricated with manifold amino acid blocks. In this study, using n-hexylamine and amine-terminated polyamidoamine dendrimers (Gx-PAMAM, x = 1-2) as initiators, a series of AMPs with linear and star-shaped topological structures were constructed via the controllable ring-opening polymerization (ROP) of N-carboxyanhydrides (NCAs). The antibacterial performances of the tailored linear and star-shaped AMPs were comprehensively evaluated in both solution states and surface-bonded states. The results indicated that the star-shaped AMPs exhibited enhanced bactericidal activity against Gram-negative E. coli and similar bactericidal activity against Gram-positive S. aureus when compared with the linear AMPs. It is worth mentioning that star-shaped AMPs demonstrated a significantly faster bactericidal efficiency (completely killed bacteria within 5 min at a concentration of 2 × MIC for S. aureus) than their linear analogues (took 15 min to achieve the same effect). However, when the AMPs were immobilized to the surface, they similarly exhibited superior antibacterial activity and fast bactericidal efficiency towards S. aureus and E. coli in the case of the same surface grafting amount. In addition, both the surfaces grafted with AMPs of different topologies demonstrated favorable biocompatibility in vitro.
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