The Association Between Asthma and Helicobacter pylori: A Meta‐Analysis

医学 哮喘 优势比 荟萃分析 幽门螺杆菌 置信区间 队列研究 内科学 入射(几何) 幽门螺杆菌感染 队列 前瞻性队列研究 子群分析 物理 光学
作者
Qiang Wang,Chaoran Yu,Yi Sun
出处
期刊:Helicobacter [Wiley]
卷期号:18 (1): 41-53 被引量:86
标识
DOI:10.1111/hel.12012
摘要

Abstract Objective The severity and incidence of asthma have increased drastically in the developed nations of the world over the last decades. Currently, some evidences indicate an inverse association between Helicobacter pylori and asthma, but some studies did not get the same conclusion. To make this question clear, we systematically reviewed the published evidence for an association between H. pylori infection and asthma. Methods Medline and SCI databases up to April 2012 were searched to identify studies that evaluated the association between H. pylori and asthma. Relevant publications were searched using the following keywords or synonyms: asthma or Helicobacter pylori . Methodologic quality was scored by using a standardized list of criteria, and meta‐analysis was conducted to calculate crude odds ratios ( OR s) with 95% confidence intervals ( CI s). Results Nineteen studies met our inclusion criteria: nine cross‐sectional studies, seven case–control studies, and three prospective cohort studies. The overall methodologic quality score was high. Pooled OR s for the association between asthma and H. pylori infection were 0.84 (95% CI : 0.74–0.96) in nine cross‐sectional studies, 0.94 (95% CI : 0.79–1.12) in seven case–control studies, and 0.82 (95% CI : 0.53–1.27) in three cohort studies. The pooled OR for all included studies was 0.81 (95% CI : 0.72–0.91) in children and 0.88 (95% CI : 0.71–1.08) in adults. Conclusions We found a weak evidence for an inverse association between asthma and H. pylori infection both in children and in adults.

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