S1154 A Comprehensive Review of the English Language Evidence Base for the Management of Paediatric Inflammatory Bowel Disease (IBD) Illustrates the Difficulties for Evidence-Based Clinical Guideline Formation

mean height Z-scores than their NGF counterparts (-0.63 vs. 0.08 for mothers; -0.36 vs. 0.28 for fathers; p<0.001).GF patients had significantly lower mean target heights based on measured parental heights (172.5 cm for males and 160 cm for females) compared to NGF patients (177.4 cm for males and 165.2 cm for females).Of 107 patients who had reached ≥ 18 years of age after study enrollment, mean final height Z-score was -1.29 for the GF group as compared to 0.06 in the NGF group.For both growth groups, the ratio of measured final height to target height was close to 1 (0.97 for GF and 0.99 for NGF).Of 31 GF patients who reached adult heights, only 9 (29%) remained in the GF group whereas 22 (71%) did not.Conclusion: Parental heights were significantly lower in GF patients with pediatric-onset IBD, and there was no significant difference between target height and patients' observed final height.Most GF patients reached their target height and were no longer growth impaired when final height was reached.Hence, genetics may be the key determinant of growth in IBD.