亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Virtual Hepatic Venous Pressure Gradient with CT Angiography (CHESS 1601): A Prospective Multicenter Study for the Noninvasive Diagnosis of Portal Hypertension

医学 门静脉压 门脉高压 肝硬化 血管造影 放射科 多中心研究 内科学 外科 随机对照试验
作者
Xiaolong Qi,Weimin An,Fuquan Liu,Ruizhao Qi,Lei Wang,Yanna Liu,Chuan Liu,Yi Xiang,Jialiang Hui,Zhao Liu,Xingshun Qi,Changchun Liu,Baogang Peng,Huiguo Ding,Yongping Yang,Xiaoshun He,Jinlin Hou,Jie Tian,Zhiwei Li
出处
期刊:Radiology [Radiological Society of North America]
卷期号:290 (2): 370-377 被引量:55
标识
DOI:10.1148/radiol.2018180425
摘要

Purpose To develop and validate a computational model for estimating hepatic venous pressure gradient (HVPG) based on CT angiographic images, termed virtual HVPG, to enable the noninvasive diagnosis of portal hypertension in patients with cirrhosis. Materials and Methods In this prospective multicenter diagnostic trial (ClinicalTrials.gov identifier: NCT02842697), 102 consecutive eligible participants (mean age, 47 years [range, 21–75 years]; 68 men with a mean age of 44 years [range, 21–73 years] and 34 women with a mean age of 52 years [range, 24–75 years]) were recruited from three high-volume liver centers between August 2016 and April 2017. All participants with cirrhosis of various causes underwent transjugular HVPG measurement, Doppler US, and CT angiography. Virtual HVPG was developed with a three-dimensional reconstructed model and computational fluid dynamics. Results In the training cohort (n = 29), the area under the receiver operating characteristic curve (AUC) of virtual HVPG in the prediction of clinically significant portal hypertension (CSPH) was 0.83 (95% confidence interval [CI]: 0.58, 1.00). The diagnostic performance was prospectively confirmed in the validation cohort (n = 73), with an AUC of 0.89 (95% CI: 0.81, 0.96). Inter- and intraobserver agreement was 0.88 and 0.96, respectively, suggesting the good reproducibility of virtual HVPG measurements. There was good correlation between virtual HVPG and invasive HVPG (R = 0.61, P < .001), with a satisfactory performance to rule out (7.3 mm Hg) and rule in (13.0 mm Hg) CSPH. Conclusion The accuracy of a computational model of virtual hepatic venous pressure gradient (HVPG) shows significant correlation with invasive HVPG. The virtual HVPG also showed a good performance in the noninvasive diagnosis of clinically significant portal hypertension in cirrhosis. © RSNA, 2018 Online supplemental material is available for this article. See also the editorial by Malayeri in this issue.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
HunterKK7发布了新的文献求助10
6秒前
轻松的惜芹应助yujie采纳,获得200
10秒前
沙雕续命完成签到,获得积分10
18秒前
19秒前
24秒前
漂亮采波发布了新的文献求助10
25秒前
开朗满天发布了新的文献求助10
30秒前
33秒前
华仔应助明亮猫咪采纳,获得10
40秒前
搜集达人应助西域小飞侠采纳,获得10
42秒前
Ava应助科研通管家采纳,获得10
42秒前
赘婿应助科研通管家采纳,获得10
43秒前
酷波er应助HunterKK7采纳,获得10
43秒前
SciGPT应助开朗满天采纳,获得10
44秒前
太清完成签到,获得积分10
47秒前
lwm不想看文献完成签到 ,获得积分10
53秒前
Djnsbj发布了新的文献求助10
57秒前
闪闪蜜粉完成签到 ,获得积分10
1分钟前
NexusExplorer应助lf采纳,获得10
1分钟前
研友_VZG7GZ应助zzq采纳,获得10
1分钟前
小马甲应助执着的夜蓉采纳,获得10
1分钟前
1分钟前
oleskarabach完成签到,获得积分20
1分钟前
1分钟前
量子星尘发布了新的文献求助10
1分钟前
丘比特应助怡然的烤鸡采纳,获得10
1分钟前
coraline26完成签到,获得积分20
1分钟前
lf发布了新的文献求助10
1分钟前
huangy发布了新的文献求助10
1分钟前
长街完成签到,获得积分20
1分钟前
夜阑卧听完成签到,获得积分10
1分钟前
123完成签到 ,获得积分10
1分钟前
在水一方应助TearMarks采纳,获得10
1分钟前
1分钟前
bbdd2334发布了新的文献求助10
1分钟前
cc完成签到,获得积分10
1分钟前
科目三应助Kongstrue采纳,获得10
1分钟前
1分钟前
李健应助bbdd2334采纳,获得10
1分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976608
求助须知:如何正确求助?哪些是违规求助? 3520720
关于积分的说明 11204567
捐赠科研通 3257359
什么是DOI,文献DOI怎么找? 1798716
邀请新用户注册赠送积分活动 877897
科研通“疑难数据库(出版商)”最低求助积分说明 806613