胶束
体内
细胞毒性
荧光素酶
体外
化学
小干扰RNA
基因传递
生物物理学
纳米技术
材料科学
癌症研究
遗传增强
转染
医学
生物化学
生物
基因
水溶液
有机化学
生物技术
作者
Haiyan Gao,Hui Feng,Biao Yan,Zhanrong Li,Lijuan Chen,Lin Jin,Junfeng Wang,El Fakhri Georges,Gang Liu,Jingguo Li,Meiyun Wang
标识
DOI:10.1166/jbn.2019.2805
摘要
Gene therapy holds tremendous promise in the treatment of tumors, in which an effective delivery system plays a crucial role. Herein, a nanoscale polymeric micelle is developed to co-deliver superparamagnetic iron oxide nanoparticles (SPIONs) and siRNA targeting luciferase gene (siLuc) into tumors. In vitro studies showed that SPIO and siRNA-loaded micelles could enter cancer cells easily and they have no cytotoxicity. And in vivo studies indicated that polymeric micelle could deliver SPIO and siRNA into tumors efficiently. Our results strongly demonstrated that the novel polymeric micelle is a promising carrier for delivery of siRNA and SPIO to enable noninvasive imaging-assisted therapy in vivo.
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