纳米柱
拉曼散射
材料科学
赭曲霉毒素A
拉曼光谱
检出限
基质(水族馆)
等离子体子
真菌毒素
纳米技术
光电子学
分析化学(期刊)
光学
化学
色谱法
纳米结构
地质学
物理
海洋学
食品科学
作者
Xiaokun Wang,Sung‐Gyu Park,Juhui Ko,Xiaofei Xu,Vincenzo Giannini,Stefan A. Maier,Dongho Kim,Jaebum Choo
出处
期刊:Small
[Wiley]
日期:2018-07-30
卷期号:14 (39)
被引量:74
标识
DOI:10.1002/smll.201801623
摘要
Abstract A surface‐enhanced Raman scattering‐based mapping technique is reported for the highly sensitive and reproducible analysis of multiple mycotoxins. Raman images of three mycotoxins, ochratoxin A (OTA), fumonisin B (FUMB), and aflatoxin B1 (AFB1) are obtained by rapidly scanning the surface‐enhanced Raman scattering (SERS) nanotags‐anchoring mycotoxins captured on a nanopillar plasmonic substrate. In this system, the decreased gap distance between nanopillars by their leaning effects as well as the multiple hot spots between SERS nanotags and nanopillars greatly enhances the coupling of local plasmonic fields. This strong enhancement effect makes it possible to perform a highly sensitive detection of multiple mycotoxins. In addition, the high uniformity of the densely packed nanopillar substrate minimizes the spot‐to‐spot fluctuations of the Raman peak intensity in the scanned area when Raman mapping is performed. Consequently, this makes it possible to gain a highly reproducible quantitative analysis of mycotoxins. The limit of detections (LODs) are determined to be 5.09, 5.11, and 6.07 pg mL −1 for OTA, FUMB, and AFB1, and these values are approximately two orders of magnitude more sensitive than those determined by the enzyme‐linked immunosorbent assays. It is believed that this SERS‐based mapping technique provides a facile tool for the sensitive and reproducible quantification of various biotarget molecules.
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