Concise Synthesis of Fungal Metabolite (+)-Fusarochromanone via Rhodium(III)-catalyzed Oxidative sp2C–H Bond Olefination

The concise synthesis of a fungal metabolite, (+)-fusarochromanone (FC-101), was achieved via the oxidative sp2 C–H bond olefination of an N-acetylaminochromanone with a chiral functionalized electron-rich alkene, catalyzed by an electron-deficient (η5-cyclopentadienyl)rhodium(III) complex, [CpERhCl2]2, under ambient conditions as the key step. This protocol was applied to various acetanilides and functionalized electron-rich alkenes for the syntheses of fusarochromanone analogs.