纳米团簇
过氧化氢酶
光动力疗法
质子化
化学
癌细胞
缺氧(环境)
癌症治疗
氧气
生物物理学
纳米技术
材料科学
组合化学
癌症
生物化学
酶
有机化学
离子
生物
遗传学
作者
Ching‐Ping Liu,Te‐Haw Wu,Chia‐Yeh Liu,Kuan‐Chung Chen,Yu‐Xing Chen,Gin‐Shin Chen,Shu‐Yi Lin
出处
期刊:Small
[Wiley]
日期:2017-05-16
卷期号:13 (26)
被引量:224
标识
DOI:10.1002/smll.201700278
摘要
Photodynamic therapy (PDT) typically involves oxygen (O 2 ) consumption and therefore suffers from greatly limited anticancer therapeutic efficacy in tumor hypoxia. Here, it is reported for the first time that amine‐terminated, PAMAM dendrimer‐encapsulated gold nanoclusters (AuNCs‐NH 2 ) can produce O 2 for PDT via their intrinsic catalase‐like activity. The AuNCs‐NH 2 not only show optimum H 2 O 2 consumption via the catalase‐like activity over the physiological pH range (i.e., pH 4.8–7.4), but also extend such activity to acidic conditions. The possible mechanism is deduced from that the enriched tertiary amines of dendrimers are easily protonated in acidic solutions to facilitate the preadsorption of OH on the metal surface, thereby favorably triggering the catalase‐like reaction. By taking advantage of the exciting feature on AuNCs‐NH 2 , the possibility to supply O 2 via the catalase‐like activity of AuNCs‐NH 2 for PDT against hypoxia of cancer cells was further studied. This proof‐of‐concept study provides a simple way to combine current O 2 ‐dependent cancer therapy of PDT to overcome cancer cell hypoxia, thus achieving more effective anticancer treatments.
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