医学
溃疡性结肠炎
重症监护医学
心理干预
养生
偏爱
生活质量(医疗保健)
药物依从性
加药
家庭医学
内科学
疾病
护理部
经济
微观经济学
作者
Kartikeya Tripathi,Jeffrey Dong,Brooke Mishkin,Joseph D. Feuerstein
摘要
Abstract: Ulcerative colitis (UC) is a chronic inflammatory disorder that requires sustained treatment for optimal outcomes. The 5-aminosalicylate (5-ASA) class of medications are first-line for the treatment of mild-to-moderate UC but suffer from suboptimal adherence rates in real-world settings. This review summarizes the literature on adherence and patient preference to 5-ASA in patients with UC. We begin by highlighting key studies that measure real-world adherence rates, as well as some of the pitfalls associated with certain techniques. We examine the data on the consequences of non-adherence, which range from decreased quality of life and higher risk of colorectal cancer at the individual level to increased costs to the overall healthcare system. We then turn to the reasons and risk factors for non-adherence and summarize the current understanding of the barriers towards adherence. Afterwards, we describe the research on patient preferences between 5-ASA formulations and dosing regimen. Finally, we summarize the evidence regarding interventions to improve 5-ASA adherence. While adherence remains a challenge in practice, understanding the current state of the field can better inform future efforts towards increasing adherence, and thus clinical outcomes, in UC. Keywords: UC, 5-ASA, ulcerative colitis, adherence, compliance
科研通智能强力驱动
Strongly Powered by AbleSci AI