The aim of this study was to evaluate secondary cancer incidence (Excess Relative Risk (ERR)) and mortality incidence (Excess Absolute Risk (EAR)) during conformal radiotherapy treatment of breast cancer. Twenty-four patients with breast cancer treated with a mono-isocentric, three-dimensional conformal radiotherapy technique were studied. The ERR and EAR were calculated using the International Commission on Radiological Protection (ICRP) risk models. The results obtained are significantly higher than those estimated by previous studies; this confirms thus the need to improve the training of health professionals involved in the management of patients.