药效团
噻唑烷二酮
脚手架
化学
戒指(化学)
组合化学
计算机科学
立体化学
医学
内分泌学
数据库
有机化学
糖尿病
2型糖尿病
作者
Juan Sun,Yue-Hu Chen,Hanyu Liu,Emmerson Hondo,Zhihui Yang,Yuanfeng Wu
标识
DOI:10.2174/1568026621666210521143550
摘要
Thiazolidinedione, an important heterocyclic ring system, is a pharmacophore and a privileged scaffold in medicinal chemistry. Researchers have shown its potential application as a backbone for inhibitors, as it is involved in anticancer development strategies, cancer progression and metastasis. In this paper, the anticancer activities of thiazolidinedione derivatives were reviewed for the first time with respect to different substituents and their positions. This work may imitate a stirring wheel to guide further advanced development of new anticancer molecules with high efficacy.
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