酰化
化学
氨基酸
衍生化
产量(工程)
激进的
呋喃
有机化学
光催化
组合化学
羧酸
噻吩
催化作用
生物化学
高效液相色谱法
光催化
冶金
材料科学
作者
Kay Merkens,Francisco José Aguilar Troyano,Khadijah Anwar,Adrián Gómez‐Suárez
标识
DOI:10.1021/acs.joc.0c02951
摘要
Herein we present a highly efficient, light-mediated, deoxygenative protocol to access γ-oxo-α-amino acid derivatives. This radical methodology employs photoredox catalysis, in combination with triphenylphosphine, to generate acyl radicals from readily available (hetero)aromatic and vinylic carboxylic acids. This approach allows for the straightforward synthesis of γ-oxo-α-amino acids bearing a wide range of functional groups (e.g., Cl, CN, furan, thiophene, Bpin) in synthetically useful yields (∼60% average yield). To further highlight the utility of the methodology, several deprotection and derivatization reactions were carried out.
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