Tuning the Structure of Nylon 6,6 Electrospun Bundles to Mimic the Mechanical Performance of Tendon Fascicles

材料科学 静电纺丝 肌腱 拐点 复合材料 纤维 脆性 极限抗拉强度 纳米纤维 韧带 过渡点 解剖 生物物理学 几何学 机械 数学 医学 物理 生物 聚合物
作者
Alberto Sensini,Michael H. Santare,Emily Eichenlaub,Ellen T. Bloom,Carlo Gotti,Andrea Zucchelli,Luca Cristofolini
出处
期刊:Frontiers in Bioengineering and Biotechnology [Frontiers Media]
卷期号:9 被引量:19
标识
DOI:10.3389/fbioe.2021.626433
摘要

Tendon and ligament injuries are triggered by mechanical loading, but the specific mechanisms are not yet clearly identified. It is well established however, that the inflection and transition points in tendon stress-strain curves represent thresholds that may signal the onset of irreversible fibrillar sliding. This phenomenon often results in a progressive macroscopic failure of these tissues. With the aim to simulate and replace tendons, electrospinning has been demonstrated to be a suitable technology to produce nanofibers similar to the collagen fibrils in a mat form. These nanofibrous mats can be easily assembled in higher hierarchical levels to reproduce the whole tissue structure. Despite the fact that several groups have developed electrospun tendon-inspired structures, an investigation of the inflection and transition point mechanics is missing. Comparing their behavior with that of the natural counterpart is important to adequately replicate their behavior at physiological strain levels. To fill this gap, in this work fascicle-inspired electrospun nylon 6,6 bundles were produced with different collector peripheral speeds (i.e., 19.7 m s –1 ; 13.7 m s –1 ; 7.9 m s –1 ), obtaining different patterns of nanofibers alignment. The scanning electron microcopy revealed a fibril-inspired structure of the nanofibers with an orientation at the higher speed similar to those in tendons and ligaments (T/L). A tensile mechanical characterization was carried out showing an elastic-brittle biomimetic behavior for the higher speed bundles with a progressively more ductile behavior at slower speeds. Moreover, for each sample category the transition and the inflection points were defined to study how these points can shift with the nanofiber arrangement and to compare their values with those of tendons. The results of this study will be of extreme interest for the material scientists working in the field, to model and improve the design of their electrospun structures and scaffolds and enable building a new generation of artificial tendons and ligaments.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
皮老师发布了新的文献求助10
刚刚
刚刚
fanmo完成签到 ,获得积分0
1秒前
1秒前
聪慧的小土豆完成签到 ,获得积分10
3秒前
3秒前
自觉的凌青完成签到,获得积分10
3秒前
5秒前
7秒前
畅快芝麻发布了新的文献求助10
7秒前
zriverm发布了新的文献求助10
9秒前
干煸鸡发布了新的文献求助10
10秒前
11秒前
12秒前
12秒前
13秒前
量子星尘发布了新的文献求助10
13秒前
呸呸晓鹏发布了新的文献求助10
17秒前
枫之林发布了新的文献求助10
18秒前
小蘑菇应助zriverm采纳,获得10
20秒前
20秒前
20秒前
SciGPT应助小鱼采纳,获得10
21秒前
学术渣渣发布了新的文献求助30
21秒前
渡劫完成签到,获得积分10
22秒前
22秒前
25秒前
靓丽雨梅完成签到 ,获得积分10
25秒前
等待的花生完成签到,获得积分10
25秒前
27秒前
Mangues发布了新的文献求助30
27秒前
呸呸晓鹏完成签到,获得积分20
27秒前
搜集达人应助xuxu采纳,获得10
28秒前
111111关注了科研通微信公众号
29秒前
29秒前
29秒前
小唐尼发布了新的文献求助30
33秒前
33秒前
37秒前
彭于晏应助gewenxue采纳,获得10
38秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989069
求助须知:如何正确求助?哪些是违规求助? 3531351
关于积分的说明 11253589
捐赠科研通 3269939
什么是DOI,文献DOI怎么找? 1804851
邀请新用户注册赠送积分活动 882074
科研通“疑难数据库(出版商)”最低求助积分说明 809073