Synergistic antibacterial effect of graphene-coated titanium loaded with levofloxacin

石墨烯 涂层 材料科学 左氧氟沙星 表面改性 化学工程 纳米技术 化学 抗生素 冶金 生物化学 工程类
作者
Jiayue Sun,Xuling Liu,Chengqi Lyu,Yinghan Hu,Derong Zou,Yu‐Shi He,Jiayu Lu
出处
期刊:Colloids and Surfaces B: Biointerfaces [Elsevier]
卷期号:208: 112090-112090 被引量:15
标识
DOI:10.1016/j.colsurfb.2021.112090
摘要

• After SLA and silanization treatment, graphene was loaded onto the titanium surface to obtain graphene-coated titanium. • Graphene-coated titanium has inherent antibacterial properties through membrane stress and the generation of ROS. • Graphene-coated titanium plays synergistic antibacterial effect through the adsorption and release of levofloxacin. • Graphene coating is a promising approach for titanium implants to prevent bacterial infections. In this study, graphene coating was introduced to the modified titanium surface to prevent bacterial infection in oral implants. We modified the titanium surface through SLA and silanization treatment and then coated the surface with graphene. The structure and surface properties were characterized by XPS and SEM. Graphene-coated titanium sheet was incubated with bacteria to test the antibacterial property, which was enhanced by adsorption and release of levofloxacin. We further implanted the graphene-coated titanium sheet loaded with levofloxacin into rabbits to test the antibacterial properties in vivo . The graphene coating exhibited inherent antibacterial properties through membrane stress and the generation of reactive oxygen species (ROS). When loaded with levofloxacin, the graphene coating exhibited a synergistic antibacterial effect and effectively prevented bacterial infections following the implantation. The graphene coating is promising to improve the antibacterial functions of oral implant surfaces to prevent bacterial infection.
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