Synthesis of ortho-Diamino-Functionalized 1-Arylnaphthalenes through Nickel-Catalyzed Cyclization of Ynamide-Benzylnitriles with Organoboronic Acids

A nickel-catalyzed highly regioselective addition/cyclization of ynamide-benzylnitriles with organoboronic acids has been developed. The reaction offers an attractive route for the construction of diamino-functionalized 1-arylnaphthalenes, which is difficult to synthesize by other methods. In addition, a wide range of functional groups are tolerated in this reaction.