高强度聚焦超声
超声波
烧蚀
低强度脉冲超声
生物医学工程
材料科学
医学
体内
聚焦超声
强度(物理)
超声波传感器
作者
Hongya Dai,Fei Chen,Sijing Yan,Xiaoya Ding,Dazhao Ma,Jing Wen,Die Xu,Jianzhong Zhang
出处
期刊:Medical Science Monitor
[International Scientific Information, Inc.]
日期:2017-07-12
卷期号:23: 3373-3382
被引量:4
摘要
BACKGROUND The aim of this study was to investigate the feasibility of the application of high-intensity focused ultrasound (HIFU) hat-type ablation mode in in vitro and in vivo models, and to compare the ablation effects of different parameter combinations. MATERIAL AND METHODS HIFU hat-type ablation was performed in isolated bovine liver tissue and in the liver tissue in living rabbits, and the coagulative necrosis for different parameter combinations (plane angles and irradiation order) was investigated. We also analyzed and compared the ablation effects of traditional ablation and hat-type ablation modes. Coagulative necrosis morphology was detected with TTC staining, and the coagulative necrosis volume and energy efficiency factor (EEF) were calculated and compared. RESULTS Coagulative necrosis was observed in all the ablated groups, and the coagulative necrosis volume was much larger than the irradiation area. The coagulative necrosis induced by the hat-type ablation was more regular and controllable than the traditional ablation. The angles between the ablation planes determined the coagulative necrosis morphology, but did not affect the coagulative necrosis volume. Moreover, the irradiation order significantly influenced the coagulative necrosis. Importantly, under certain conditions, hat-type ablation achieved higher efficiency compared with the traditional ablation mode. CONCLUSIONS Compared with the traditional ablation mode, HIFU hat-type ablation effectively shortened the irradiation time, reduced the over-accumulation of energy, and increased the HIFU ablation efficiency.
科研通智能强力驱动
Strongly Powered by AbleSci AI