[Research progress of ocular sustained-release corticosteroid delivery systems].

Ocular drug delivery by conventional routes of administration cannot reach or maintain therapeutic drug concentrations in the target tissues for a long duration due to the presence of various anatomical and physiological barriers. Treatment of chronic ocular diseases especially posterior segment of ocular diseases requires novel drug delivery systems that is capable overcome these barriers for efficacious delivery. In recent years, the ocular sustained-release drug delivery system, as a new drug delivery approach, has drawn tremendous attention for its advantages of improving local drug concentration, prolonging action time and reducing frequency of injection. Researchers have been devoted to the developing more effective sustained-release drug delivery systems in order to achieve better clinical efficacy. This article discusses various current sustained-release corticosteroids delivery systems. (Chin J Ophthalmol, 2018, 54: 154-160).由于各种眼内屏障的存在，传统的眼部给药途径很少可以在靶组织内达到或有效保持药物的治疗浓度。多种慢性眼部疾病尤其眼后部疾病需要更为有效的药物递送系统，以克服传统给药途径的缺陷。眼内药物缓释系统作为新兴的给药方式，由于可以有效提高局部药物浓度、延长药物作用时间、减少注射频次而受到临床关注。研究者致力于开发更为有效的眼内药物缓释系统，以期提高相关眼病的治疗效果。本文对眼部糖皮质激素缓释系统的研究进展进行总结和分析，以期为相关研究提供资料和参考。（中华眼科杂志，2018，54：154-160）.