Characterization of Rubia cordifolia L. root extract and its evaluation of cardioprotective effect in Wistar rat model

植物化学 化学 抗氧化剂 传统医学 超氧化物歧化酶 蒽醌类 过氧化氢酶 谷胱甘肽 药理学 生物化学 生物 植物 医学
作者
S Prabhakara,Kolandaswamy Anbazhagan,B. S. Chandrashekar,T. C. K. Mohan,D Shabeer,Basavaraj Bhandare,Monnanda Somaiah Nalini,P. Sharmila,DL Meghana,BasanthKumar Reddy,HM Hanumantha Rao,H Sahajananda
出处
期刊:Indian Journal of Pharmacology [Medknow Publications]
卷期号:50 (1): 12-12 被引量:30
标识
DOI:10.4103/ijp.ijp_418_17
摘要


OBJECTIVES: Rubia cordifolia L. (RC) is a well-known and highly valuable medicinal plant in the Ayurvedic system. The present study involves evaluating antioxidant and cardioprotective property of RC root extract.
MATERIALS AND METHODS: The characterization of RC root extract was carried out using standard phytochemical and biochemical analysis. The functional groups were analyzed by Fourier transform infrared (FTIR) spectroscopy and phytotherapeutic compounds were identified using high-resolution mass spectrometry (HR-MS). Cardioprotective activity of RC root extract was investigated against cyclophosphamide (CP; 100 mg/kg, i.p)-induced cardiotoxicity in male albino Wistar rats. RC (100, 200, and 400 mg/kg, p.o) or silymarin (100 mg/kg, p.o) was administered immediately after CP on the 1st day and the next consecutive 10 days. Biochemical and histopathological analysis was performed to observe the cardioprotective effects of RC root extract.
RESULTS: Phytochemical analysis revealed the presence of secondary metabolites that include alkaloids, flavonoids, saponins, and anthraquinones in RC root extract. FTIR analysis revealed the presence of several functional groups. Based on HR-MS analysis, eight major phytotherapeutic compounds were identified in methanol root extract of RC. Biochemical analysis in CP-induced rat model administered with RC extract revealed significantly enhanced levels of antioxidant markers such as superoxide dismutase, catalase, and glutathione S-transferase. Histopathological study showed that the rat model treated with the root extract had reduced the cardiac injury.
CONCLUSION: Our results have shown that the RC extract contains various antioxidant compounds with cardioprotective effect. Treatment with RC root extract could significantly protect CP-induced rats from cardiac tissue injury by restoring the antioxidant markers.
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