高尿酸血症
药效团
虚拟筛选
灰树花
化学
黄嘌呤氧化酶
尿酸
药理学
生物化学
生物
酶
多糖
作者
Tianqiao Yong,Yizhen Xie,Shaodan Chen,Diling Chen,Jiyan Su,Chunwei Jiao,Huiping Hu,Chun Xiao
标识
DOI:10.1016/j.jff.2017.11.049
摘要
Grifola frondosa (GF) has been exploited as herb medicine for metabolic diseases and also as tasty food in Asia. Water (GFW) and ethanol (GFE) extracts produced remarkable hypouricemic effects, thereby decreasing the levels of serum uric acid from 240 μmol/L (hyperuricemia control, P < .01) to 170, 169, and 153 μmol/L for GFW at doses of 30, 60, and 120 mg/kg and to 169, 168, and 156 μmol/L for GFE at 50, 100, and 200 mg/kg correspondingly, which were similar to the normal control (159 μmol/L). ELISA analysis demonstrated the inhibitory effects of GFW and GFE on URAT1 protein rather than xanthine oxidase (XOD). The 3D-QSAR pharmacophore model for URAT1 was established successfully. Four compounds were identified and mapped adequately, deserving further study. Taken together, G. frondosa is a promising candidate for the development of functional foods.
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