纳米技术
药物输送
行动地点
脂质体
诱导多能干细胞
药品
医学
药理学
化学
材料科学
胚胎干细胞
内科学
生物化学
基因
作者
Roshni Iyer,Connie C. W. Hsia,Kytai T. Nguyen
标识
DOI:10.2174/1381612821666150923095742
摘要
Inhalation of aerosolized compounds is a popular, non-invasive route for the targeted delivery of therapeutic molecules to the lung. Various types of nanoparticles have been used as carriers to facilitate drug uptake and intracellular action in order to treat lung diseases and/or to facilitate lung repair and growth. These include polymeric nanoparticles, liposomes, and dendrimers, among many others. In addition, nanoparticles are sometimes used in combination with small molecules, cytokines, growth factors, and/or pluripotent stem cells. Here we review the rationale and state-of-the-art nanotechnology for pulmonary drug delivery, with particular attention to new technological developments and approaches as well as the challenges associated with them, the emerging advances, and opportunities for future development in this field.
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