Current Progress in Understanding the Mechanism of Immune Regulation of Classical Transient Receptor Potential 1 (TRPC1)

瞬时受体电位通道(Transient receptor potential channel 1, TRPC1)是位于细胞膜上的一类非电压依赖性的阳离子通道蛋白，其主要参与细胞内Ca2+稳态的调节。近年研究证明，TRPC1在细胞增殖、分化、凋亡等生物学行为方面起着重要的作用，与多种生理病理过程密切相关。本文主要对TRPC1的免疫调控效应及其机制做一简要综述。 Transient receptor potential channel 1 (TRPC1) is a nonselective cation channel protein that is required for Ca2+ homeostasis. Recently, more and more evidences have certificated that TRPC1 is necessary for the cellular functions, such as cell proliferation, differentiation and apoptosis, and involved in diverse physiological processes. This paper mainly reviews the progress in understanding the function of TRPC1 in immune regulation.