New Cembranoids from Tobacco, II

The methylethers 4-O,8-O-dimethyl-(1S, 2E, 4R, 6E, 8S, 11E)-2,6,11-cembratriene-4,8-diol (9), 4-O-methyl-(1S, 2E, 4R, 7E, 11E)-2,7,11-cembratriene-4,6-diol (4) und 4-O,6-O-methyl-(1S, 2E, 4R, 7E, 11E)-2,7,11-cembratriene-4,6-diol (8) were identified as new natural products from tobacco. They were isolated from processed tobacco as well as from leaf surface gum of fresh tobacco. The spectral data of all six methylethers of (1S, 2E, 4S, 6R, 7E, 11E)- and (1S, 2E, 4R, 6R, 7E, 11E)-2,7,11-cembratrienen-4,6-diol are given.