成纤维细胞生长因子受体
成纤维细胞生长因子
癌症研究
肺癌
癌症
受体
信号转导
医学
生物
表皮生长因子受体
内科学
细胞生物学
作者
Federica Biello,Giovanni Burrafato,Erika Rijavec,Carlo Genova,Giulia Barletta,Anna Truini,Simona Coco,Maria Giovanna Dal Bello,Angela Alama,Francesco Boccardo,Francesco Grossi
出处
期刊:Anti-cancer Agents in Medicinal Chemistry
[Bentham Science]
日期:2016-08-16
卷期号:16 (9): 1142-1154
被引量:8
标识
DOI:10.2174/1871520616666160204112347
摘要
Lung cancer is still the leading cause of cancer related death worldwide. Fibroblast growth factor receptor (FGFR) is a tirosine-kinase receptor that is seen to be amplified or mutated in non-small cell lung cancer (NSCLC) and it plays a crucial role in tumour development and maintenance. The authors analyzed the state of the art of FGFR by reviewing the current literature. Fibroblast growth factor (FGF)-FGFR pathway and their aberrations are described, with the evaluation of their possible prognostic role in NSCLC and in particular in squamous cell carcinomas, in which FGFR is more often amplified. New therapeutic agents targeting FGFR signaling have been developed and are now in clinical evaluation. Dysregulation of FGF signaling in tumour cells is related to FGFR gene amplification or mutation, although it is still uncertain which of these aberrations represents a real predictor of response to specific inhibitors. However, recent evidence has questioned whether FGFR is a real target in squamous cell histology. The effectiveness of FGFR inhibitors is also still unclear since there are no clinical data on selected patients. Moreover, the management of specific side effects related to inhibition of the physiological role of FGF should be more thorough.
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