促炎细胞因子
活性氧
肿瘤坏死因子α
化学
氧化应激
下调和上调
癌症研究
纤维肉瘤
肿瘤微环境
活性氮物种
体内
细胞生物学
炎症
生物化学
免疫学
生物
医学
病理
生物技术
基因
肿瘤细胞
作者
Ramkrishna Pal,Biswajit Chakraborty,Anupam Nath,Leichombam Mohindro Singh,M. Azam Ali,Dewan S. Rahman,Sujit Kumar Ghosh,Abhishek Basu,Sudin Bhattacharya,Rathindranath Baral,Mahuya Sengupta
标识
DOI:10.1016/j.intimp.2016.06.006
摘要
Diagnosis of cancer and photothermal therapy using optoelectronic properties of noble metal nanoparticles (NPs) has established a new therapeutic approach for treating cancer. Here we address the intrinsic properties of noble metal NPs (gold and silver) as well as the mechanism of their potential antitumor activity. For this, the study addresses the functional characterization of tumor associated macrophages (TAMs) isolated from murine fibrosarcoma induced by a chemical carcinogen, 3-methylcholanthrene (MCA). We have previously shown antitumor activity of both gold nanoparticles (AuNPs) and silver nanoparticle (AgNPs) in vivo in a murine fibrosarcoma model. In the present study, it has been seen that AuNPs and AgNPs modulate the reactive oxygen species (ROS) and reactive nitrogen species (RNS) production, suppressing the antioxidant system of cells (TAMs). Moreover, the antioxidant-mimetic action of these NPs maintain the ROS and RNS levels in TAMs which act as second messengers to activate the proinflammatory signaling cascades. Thus, while there is a downregulation of tumor necrosis factor-α (TNF-α) and Interleukin-10 (IL-10) in the TAMs, the proinflammatory cytokine Interleukin-12 (IL-12) is upregulated resulting in a polarization of TAMs from M2 (anti-inflammatory) to M1 (pro-inflammatory) nature.
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