The efficacy and safety of probiotics for prevention of chemoradiotherapy-induced diarrhea in people with abdominal and pelvic cancer: a systematic review and meta-analysis

医学 腹泻 内科学 荟萃分析 科克伦图书馆 随机对照试验 优势比 不利影响 安慰剂 替代医学 病理
作者
Y-H Wang,Nan Yao,K-K Wei,Li Jiang,Shahbaz Hanif,Zixuan Wang,C-X Pei
出处
期刊:European Journal of Clinical Nutrition [Springer Nature]
卷期号:70 (11): 1246-1253 被引量:64
标识
DOI:10.1038/ejcn.2016.102
摘要

A systematic review and meta-analysis were designed to evaluate the efficacy and safety of probiotics for prevention of chemoradiotherapy-induced diarrhea in people with abdominal and pelvic cancer. We searched the Cochrane Library, PubMed, EMBASE and Web of Science up to November 2015. We also hand searched the citation lists of included studies and previously identified systematic reviews to identify further relevant trials. Odds ratio (OR) was used to compare efficacy, and the pooled OR was estimated using a random effects model; heterogeneity was assessed with Cochran's Q and the Higgins' I2-test. Two reviewers assessed trial quality and extracted data independently. Analysis and bias for each included study were performed using Review Manager 5.2. Nine randomized and placebo-controlled studies (N=1265 participants) were included for assessing efficacy, of which seven were about radiotherapy and two about chemotherapy. Probiotic groups were compared with control groups with respect to the the incidence of diarrhea, OR=0.47 (95% confidence interval 0.28-0.76; P=0.002). Eleven studies, including 1612 people (873 consuming probiotics and 739 not consuming probiotics), were used for the analysis of safety of probiotics. Of the 11 studies, seven studies had no adverse events (AEs) caused by probiotics, whereas four studies reported varying degrees of AEs in their treatment. Probiotics may have a beneficial effect in prevention of chemoradiotherapy-induced diarrhea generally, especially for Grade⩾2 diarrhea. Probiotics may rarely cause AEs.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
打打应助zhl采纳,获得10
1秒前
lang完成签到,获得积分10
1秒前
ChouNen完成签到,获得积分10
1秒前
专注夜南完成签到,获得积分20
1秒前
叶子发布了新的文献求助10
2秒前
大分子完成签到,获得积分10
2秒前
阳光青烟完成签到,获得积分10
2秒前
艺玲完成签到,获得积分10
3秒前
俊逸沛菡完成签到 ,获得积分10
3秒前
YXH发布了新的文献求助10
3秒前
守护星星完成签到,获得积分10
4秒前
Lucas应助Fyyyyyyyyyz采纳,获得10
4秒前
找不到完成签到,获得积分0
4秒前
温乘云完成签到,获得积分10
5秒前
斯文败类应助lei采纳,获得10
5秒前
英俊的胜完成签到,获得积分10
6秒前
隐形曼青应助首席或雪月采纳,获得10
6秒前
7秒前
7秒前
orixero应助光亮靖琪采纳,获得10
7秒前
科研通AI2S应助自觉的怜阳采纳,获得10
7秒前
爆米花应助guchenniub采纳,获得10
7秒前
Ivia完成签到,获得积分10
8秒前
Hello应助至秦采纳,获得10
9秒前
小星星完成签到,获得积分10
9秒前
10秒前
NexusExplorer应助胜东采纳,获得10
10秒前
耿昭完成签到,获得积分10
11秒前
楼台杏花琴弦完成签到,获得积分10
11秒前
wy.he应助hegui采纳,获得10
12秒前
Depeng完成签到,获得积分10
12秒前
搜集达人应助面包会游泳采纳,获得10
13秒前
汉堡包应助江峰采纳,获得10
13秒前
Lucas应助zky17715002采纳,获得10
13秒前
犹豫的世倌完成签到,获得积分10
14秒前
浅色墨水完成签到,获得积分10
14秒前
Baitingjie完成签到,获得积分20
14秒前
ddjl完成签到,获得积分20
14秒前
甜酒完成签到 ,获得积分10
14秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 1000
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3245091
求助须知:如何正确求助?哪些是违规求助? 2888863
关于积分的说明 8255782
捐赠科研通 2557216
什么是DOI,文献DOI怎么找? 1385884
科研通“疑难数据库(出版商)”最低求助积分说明 650265
邀请新用户注册赠送积分活动 626473