褐藻糖胶
淋巴管新生
淋巴管内皮
癌症研究
淋巴系统
PI3K/AKT/mTOR通路
血管内皮生长因子C
医学
转移
细胞生物学
生物
免疫学
血管内皮生长因子
信号转导
癌症
内科学
血管内皮生长因子A
生物化学
多糖
血管内皮生长因子受体
作者
Yazong Yang,Zixiang Gao,Yanhong Ma,Hongming Teng,Zundong Liu,Hengyun Wei,Yanbing Lu,Xiaofang Cheng,Lin Hou,Xiangyang Zou
出处
期刊:Oncotarget
[Impact Journals, LLC]
日期:2016-05-18
卷期号:7 (25): 38025-38035
被引量:18
标识
DOI:10.18632/oncotarget.9443
摘要
Lymphangiogenesis is one of the promoters of tumor lymphatic metastasis. Fucoidan which is a fucose-enriched sulfated polysaccharide has effect on various pharmacological activities including anti-metastasis activity. However, the inhibitory effect of fucoidan on lymphangiogenesis remains unclear. Here, fucoidan extracted from U. pinnatifida sporophylls suppressed HLECs proliferation, migration and tube-like structure formation, and had inhibitory effect of tumor-induced lymphangiogenesis in vitro. Additionally, we found that fucoidan had a dose-dependent depressive effect on the expressions of PROX1, vascular endothelial growth factor receptor 3 (VEGFR3), NF-κB, phospho-PI3K and phospho-Akt in HLECs. Moreover, anti-lymphangiogenesis effect of fucoidan was assessed by using mouse tumor model. In summary, fucoidan inhibit tumor lymphangiogenesis and lymphatic metastasis by suppressing the NF-κB/PI3K/Akt signaling pathway through reduced levels of PROX1 and VEGFR3.
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