体内
纳米颗粒
化学
生物相容性材料
辐照
体外
细胞毒性
核化学
纳米技术
生物物理学
材料科学
生物化学
生物医学工程
生物
医学
物理
生物技术
核物理学
作者
Zhanhua Wang,Chuan Gao,Xuwen Da,Jian Yao,Chao Zhang,Yishan Yao,Xuesong Wang,Qianxiong Zhou
出处
期刊:Dalton Transactions
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:51 (8): 3225-3233
被引量:2
摘要
Chemodynamic therapy (CDT) is novel and promising for cancer treatment, however, the potential systematic toxicity of the used nanoparticles is still a big concern. In this work the biocompatible hypocrellin A-Fe(III) nanoparticles (HA-Fe(III) NPs) were synthesized and studied. The CDT effect of HA-Fe(III) NPs in the dark is negligible but can be photo-activated upon red light irradiation, which is meaningful to realize precise CDT treatment by selective light irradiation. Moreover, HA-Fe(III) NPs can also generate O2˙-, which may be converted into H2O2 to further enhance the CDT effect. As a result, HA-Fe(III) NPs had little cytotoxicity in the dark at the concentration up to 200 μg ml-1, but exhibited efficient CDT activity upon red light irradiation under both normoxic and hypoxic conditions. The in vivo results also showed that HA-Fe(III) NPs can efficiently inhibit tumor growth upon 628 nm light irradiation.
科研通智能强力驱动
Strongly Powered by AbleSci AI