悬挂(拓扑)
材料科学
色谱法
化学
数学
同伦
纯数学
作者
Vivek Agrahari,Onkar Singh
出处
期刊:AAPS advances in the pharmaceutical sciences series
日期:2021-01-01
卷期号:: 317-347
被引量:2
标识
DOI:10.1007/978-3-030-76367-1_12
摘要
Drug delivery to the ocular diseases requires strategic approaches due to the existence of anatomical/static and physiological/dynamic barriers. Several ophthalmic conventional topical formulations are designed as solutions, suspensions, ointments, or emulsions to achieve an effective drug dose to the ocular tissues. In addition, various novel nanoformulation-based delivery systems have been explored through various routes of administration and showed promising results. In this book chapter, we briefly reviewed the routes of administration, ocular barriers with an emphasis on the topical route of drug administration, and the development of ocular suspension and nanosuspension formulations. The considerations in formulation development of suspension dosage forms are discussed to facilitate the development of safe, stable, and efficacious drug products. Moreover, the factors affecting the stability of suspensions/nanosuspensions and approaches to develop a stable product are summarized.
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