胰岛素抵抗
医学
糖尿病
2型糖尿病
肥胖
疾病
代谢综合征
促炎细胞因子
病理生理学
生物信息学
重症监护医学
内科学
内分泌学
炎症
生物
作者
Robert H. Eckel,Scott M. Grundy,Paul Zimmet
出处
期刊:The Lancet
[Elsevier]
日期:2005-04-01
卷期号:365 (9468): 1415-1428
被引量:4962
标识
DOI:10.1016/s0140-6736(05)66378-7
摘要
Summary
The metabolic syndrome is a common metabolic disorder that results from the increasing prevalence of obesity. The disorder is defined in various ways, but in the near future a new definition(s) will be applicable worldwide. The pathophysiology seems to be largely attributable to insulin resistance with excessive flux of fatty acids implicated. A proinflammatory state probably contributes to the syndrome. The increased risk for type 2 diabetes and cardiovascular disease demands therapeutic attention for those at high risk. The fundamental approach is weight reduction and increased physical activity; however, drug treatment could be appropriate for diabetes and cardiovascular disease risk reduction.
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