化学
烷基化
亲核细胞
催化作用
钴
噻吩
对映选择合成
烷基
弗里德尔-克拉夫茨反应
组合化学
有机化学
药物化学
作者
Tao Qin,Guowei Lv,Huanran Miao,Meihui Guan,Chunlu Xu,Ge Zhang,Tao Xiong,Qian Zhang
标识
DOI:10.1002/anie.202201967
摘要
An efficient and general intermolecular Cobalt(II)-catalyzed asymmetric alkylation of styrenes with (hetero)arenes including indoles, thiophene and electron rich arenes has been developed, providing straightforward access to enantioenriched alkyl(hetero)arenes with high enantioselectivity. Mechanistic studies suggest that the reaction underwent a CoH-mediated hydrogen atom transfer (HAT) with alkenes, followed by a pivotal catalyst-controlled SN 2-like pathway between in situ generated organocobalt(IV) species and aromatic nucleophiles. This is the first CoH-catalyzed asymmetric hydrofunctionalization using carbon nucleophiles, providing a new strategy for asymmetric Friedel-Crafts type alkylation.
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