药物输送
纳米技术
生物利用度
金属有机骨架
背景(考古学)
药品
纳米材料
材料科学
药理学
医学
化学
有机化学
吸附
古生物学
生物
作者
Yu Liu,Li Li,Zhaorui Qi,Shasha Han,Xurui Li,Bing‐Mi Liu
出处
期刊:Mini-reviews in Medicinal Chemistry
[Bentham Science]
日期:2022-11-01
卷期号:22 (20): 2564-2580
被引量:5
标识
DOI:10.2174/1389557522666220330152145
摘要
Abstract: Oral administration is a commonly used, safe, and patient-compliant method of drug delivery. However, due to the multiple absorption barriers in the gastrointestinal tract (GIT), the oral bioavailability of many drugs is low, resulting in a limited range of applications for oral drug delivery. Nanodrug delivery systems have unique advantages in overcoming the multiple barriers to oral absorption and improving the oral bioavailability of encapsulated drugs. Metal-organic frameworks (MOFs) are composed of metal ions and organic linkers assembled by coordination chemistry. Unlike other nanomaterials, nanoscale metal-organic frameworks (nano-MOFs, NMOFs) are increasingly popular for drug delivery systems (DDSs) due to their tunable pore size and easily modified surfaces. This paper summarizes the literature on MOFs in pharmaceutics included in SCI for the past ten years. Then, the GIT structure and oral drug delivery systems are reviewed, and the advantages, challenges, and solution strategies possessed by oral drug delivery systems are discussed. Importantly, two major classes of MOFs suitable for oral drug delivery systems are summarized, and various representative MOFs as oral drug carriers are evaluated in the context of oral drug delivery systems. Finally, the challenges faced by DDSs in the development of MOFs, such as biostability, biosafety, and toxicity, are examined.
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