化学
烷基
催化作用
有机化学
三氟甲基
基质(水族馆)
卤化物
镍
组合化学
对映选择合成
海洋学
地质学
作者
Wenqing Guo,Cheng Li,Guobin Ma,Weiqi Tong,Fan Wu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-03-02
卷期号:24 (9): 1796-1801
被引量:16
标识
DOI:10.1021/acs.orglett.2c00148
摘要
Here, we report a nickel-catalyzed enantioconvergent hydroalkylation of olefins with trifluoromethyl-containing α-alkyl halides for the synthesis of enantioenriched trifluoromethylated alkanes. This reaction employs readily available and bench-stable alkenes as alkyl coupling partners, featuring mild conditions, a broad substrate scope, and high functional group tolerance. The synthetic utility of this method is further demonstrated in the late-stage functionalization of a range of drug molecules and natural products.
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