Aminocatalytic Alkylation of Indene‐2‐Carbaldehydes via Pentaenamine Activation

Abstract In the manuscript an application of amino isobenzofulvene intermediates as pentaenamines undergoing 1,6‐addition is described. As a result an alkylation of the indene ring of the starting indene‐2‐carbaldehydes with para ‐quinone methides is achieved. Stereoselectivity of the process is controlled by C 2 ‐symmetric 2,5‐diphenylpyrrolidine. The developed process exploits the reactivity of amino isobenzofulvene intermediates derived from indene‐2‐carbaldehydes in a non‐cycloadditive manner. magnified image