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Hippocampal Subfield Volumes and Cognitive Function in Schizophrenia and Mood Disorders

下托 海马结构 心理学 齿状回 神经认知 重性抑郁障碍 双相情感障碍 海马体 精神分裂症(面向对象编程) 神经科学 认知 情绪障碍 内科学 医学 精神科 焦虑
作者
Kasumi Yasuda,Shinichi Yamada,Shinya Uenishi,Natsuko Ikeda,Atsushi Tamaki,Yuji Ohoshi,Tomikimi Tsuji,Shun Takahashi
出处
期刊:Neuropsychobiology [Karger Publishers]
卷期号:81 (3): 204-214 被引量:11
标识
DOI:10.1159/000521102
摘要

The hippocampus is relevant to cognitive function in schizophrenia (SCZ) and mood disorder patients. Although not anatomically uniform, it is clearly divided into subfields. This study aimed to elucidate the relationship between hippocampal subfield volume and cognitive function in patients with SCZ, bipolar disorder (BP), and major depressive disorder (MDD).The study included 21 patients with SCZ, 22 with BP, and 21 with MDD and 25 healthy controls (HCs). Neurocognitive function was assessed using the Brief Assessment of Cognition in Schizophrenia. We obtained hippocampal subfield volumes using FreeSurfer 6.0. We compared the volumes of the hippocampal subfield between the 4 groups and ascertained correlation between the cognitive composite score and hippocampal subfield volume in each group.The SCZ group had significantly lower cognitive composite score than the BP, MDD, and HC groups. In the SCZ group, the left and right hippocampus-amygdala transition area and right subiculum and right presubiculum volumes were significantly reduced compared to those in the HC group. The left presubiculum volumes in the SCZ group were significantly reduced compared to those in the MDD group. Subfield volumes did not significantly differ between the BP, MDD, and HC groups. Interestingly, in the SCZ group, volumes of the right CA1, right molecular layer of the hippocampus, and right granule cell and molecular layer of the dentate gyrus were significantly correlated with the cognitive composite score.Patients with SCZ had poorer cognitive function, which is related to their hippocampal pathology, than those with mood disorders.
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