海绵
羧甲基纤维素
壳聚糖
伤口愈合
止血
体内
化学
血管生成
抗菌剂
多糖
淀粉
体外
银纳米粒子
纤维素
材料科学
核化学
微生物学
纳米颗粒
生物化学
纳米技术
免疫学
生物
有机化学
癌症研究
医学
植物
外科
生物技术
钠
作者
Linyu Long,Cheng Hu,Wenqi Liu,Can Wu,Lu Lu,Li Yang,Yunbing Wang
出处
期刊:Biomaterials advances
日期:2022-04-01
卷期号:135: 112669-112669
被引量:19
标识
DOI:10.1016/j.msec.2022.112669
摘要
Herein, a novel microfibrillated cellulose (MFC) reinforced natural polymer-based sponge composed of carboxymethyl chitosan (CMC) and oxidized starch (OS) with hemostatic, repairing-promoting, and antimicrobial performances was fabricated for chronic wound repair. When the content of MFC reached 1.2 wt%, the prepared sponge exhibited ultra-fast water or blood-trigged shape recovery property within 3 s. Moreover, sponge was functionally modified with silver nanoparticles (AgNPs) and recombinant humanized collagen type III (rhCol III). The AgNPs and rhCol III loaded sponge (A-Ag/III) could effectively kill a broad spectrum of pathogenic microbes, promote the proliferation and migration of L929 cells in vitro. Due to their erythrocyte-aggregating ability and positive-charge feature of CMC, the A-Ag/III displayed rapid hemostasis ability. Furthermore, the in vivo animal experiment demonstrated the A-Ag/III could promote wound repair by inhibiting inflammation, promoting angiogenesis, and cell proliferation.
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