传染性
细胞
病毒学
传输(电信)
细胞融合
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
生物
电池类型
2019年冠状病毒病(COVID-19)
病毒进入
病毒
细胞生物学
病毒复制
遗传学
医学
计算机科学
疾病
病理
传染病(医学专业)
电信
作者
Cong Zeng,John P. Evans,Tiffany King,Yi-Min Zheng,Eugene M. Oltz,Sean P. J. Whelan,Linda J. Saif,Mark E. Peeples,Shan‐Lu Liu
标识
DOI:10.1073/pnas.2111400119
摘要
Significance It is currently unknown if SARS-CoV-2 can spread through cell–cell contacts, and if so, the underlying mechanisms and implications. In this work, we show, by using lentiviral pseudotyped virus, that the spike protein of SARS-CoV-2 mediates the viral cell-to-cell transmission, with an efficiency higher than that of SARS-CoV. We also find that cell–cell fusion contributes to cell-to-cell transmission, yet ACE2 is not absolutely required. While the authentic variants of concern (VOCs) B.1.1.7 (alpha) and B.1.351 (beta) differ in cell-free infectivity from wild type and from each other, these VOCs have similar cell-to-cell transmission capability and exhibit differential sensitivity to neutralization by vaccinee sera. Results from our study will contribute to a better understanding of SARS-CoV-2 spread and pathogenesis.
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