前列腺癌
蛋白激酶B
PI3K/AKT/mTOR通路
癌症
前列腺
细胞凋亡
癌症研究
药理学
化学
医学
内科学
生物化学
作者
Bexultan Kazybay,Qing-lei Sun,Kanat Dukenbayev,Ayan Nurkesh,Na Xu,А. Н. Кутжанова,Madina Razbekova,Anar Kabylda,Qing Yang,Qian Wang,Cuiping Ma,Yingqiu Xie
出处
期刊:ACS omega
[American Chemical Society]
日期:2022-04-18
卷期号:7 (17): 14465-14477
被引量:12
标识
DOI:10.1021/acsomega.1c03018
摘要
A combination therapy of RhizomaPolygonati (RP) with goji (Lycium chinense) has earned a long history in the prescriptions to promote male health. However, the mechanisms at both molecular and nanoscale quantum levels are unclear. Here, we found that processed RP extract induces apoptosis and cell cycle arrest in cancer cells, thereby inhibiting prostate cancer cell proliferation enhanced by processed goji extract associated with an augment of the nanoscale herbzyme of phosphatase. For network pharmacology analysis, RP-induced PI3K-AKT pathways are essential for both benign prostatic hyperplasia and prostate cancer, and the RP/goji combination induces potent pathways which include androgen and estrogen response, kinase regulation, apoptosis, and prostate cancer singling. In addition, the experimental investigation showed that the prostate cancer cells are sensitive to RP extract for inhibiting colony formation. Finally, the natural compound baicalein found in RP ingredients showed a linked activity of top-ranked signaling targets of kinases including MAPK, AKT, and EGFR by the database of cMAP and HERB. Thus, both the nanozyme and ingredients might contribute to the RP in anti-prostate cancer which can be enhanced by goji extract. The proposed nanoscale RP extract might be of significance in developing novel anti-prostate cancer agents by combining goji compositions and targeted therapy compounds.
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