青光眼
视神经
视神经病变
医学
细胞外基质
神经退行性变
眼压
视网膜神经节细胞
神经科学
眼科
光盘
生物
病理
疾病
细胞生物学
作者
Ryan G. Strickland,Mary Anne Garner,Alecia K. Gross,Christopher A Girkin
摘要
Glaucomatous optic neuropathy is the leading cause of irreversible blindness in the world. The chronic disease is characterized by optic nerve degeneration and vision field loss. The reduction of intraocular pressure remains the only proven glaucoma treatment, but it does not prevent further neurodegeneration. There are three major classes of cells in the human optic nerve head (ONH): lamina cribrosa (LC) cells, glial cells, and scleral fibroblasts. These cells provide support for the LC which is essential to maintain healthy retinal ganglion cell (RGC) axons. All these cells demonstrate responses to glaucomatous conditions through extracellular matrix remodeling. Therefore, investigations into alternative therapies that alter the characteristic remodeling response of the ONH to enhance the survival of RGC axons are prevalent. Understanding major remodeling pathways in the ONH may be key to developing targeted therapies that reduce deleterious remodeling.
科研通智能强力驱动
Strongly Powered by AbleSci AI