生物标志物
急性胰腺炎
病理生理学
胰腺炎
线粒体DNA
疾病
医学
炎症
线粒体
程序性细胞死亡
诊断生物标志物
病理
内科学
细胞凋亡
生物信息学
胃肠病学
免疫学
生物
细胞生物学
基因
遗传学
作者
William Yakah,Ishani Shah,Disha Skelton-Badlani,Steven D. Freedman,Yury Popov,Sunil G. Sheth,Awais Ahmed,Pinzhu Huang,Ankit Chhoda,Konstantin Khrapko
标识
DOI:10.1053/j.gastro.2023.01.013
摘要
Acute pancreatitis (AP) is a leading cause of gastrointestinal hospital admissions with up to 40% mortality in moderate to severe AP. 1 Boxhoorn L. et al. Lancet. 2020; 396: 726-734 Abstract Full Text Full Text PDF PubMed Scopus (221) Google Scholar Cell death and inflammation are key processes in the pathophysiology of AP, and mitochondria-mediated cell death plays a central role in the initiation of inflammatory pathways of AP. 2 Krysko D.V. et al. Trends Immunol. 2011; 32: 157-164 Abstract Full Text Full Text PDF PubMed Scopus (483) Google Scholar Evidence suggests that several damage-associated molecular patterns (DAMPs) are released from dead pancreatic acinar mitochondria into the extracellular circulation. Given the need for early diagnosis of AP severity for proper treatment, we investigated whether circulating levels of mitochondrial DNA (mtDNA) fragments are a potential biomarker of early distinction for AP severity.
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