H3K4me3
组蛋白甲基转移酶
表观遗传学
组蛋白密码
染色质
组蛋白
表观遗传学
生物
EZH2型
遗传学
组蛋白H3
甲基转移酶
计算生物学
组蛋白甲基化
细胞生物学
DNA
基因
发起人
DNA甲基化
基因表达
核小体
甲基化
作者
Michelle N. Yancoskie,Corina Maritz,Patrick van Eijk,Simon H. Reed,Hanspeter Naegeli
标识
DOI:10.1016/j.tibs.2022.10.003
摘要
The concept of the histone code posits that histone modifications regulate gene functions once interpreted by epigenetic readers. A well-studied case is trimethylation of lysine 4 of histone H3 (H3K4me3), which is enriched at gene promoters. However, H3K4me3 marks are not needed for the expression of most genes, suggesting extra roles, such as influencing the 3D genome architecture. Here, we highlight an intriguing analogy between the H3K4me3-dependent induction of double-strand breaks in several recombination events and the impact of this same mark on DNA incisions for the repair of bulky lesions. We propose that Su(var)3–9, Enhancer-of-zeste and Trithorax (SET)-domain methyltransferases generate H3K4me3 to guide nucleases into chromatin spaces, the favorable accessibility of which ensures that DNA break intermediates are readily processed, thereby safeguarding genome stability.
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