A Contemporary Clinicopathologic Analysis of Primary Sarcomas of the Perinephric Soft Tissue and Hilar Vessels Including a Subset Secondarily Involving the Kidney

平滑肌肉瘤 脂肪肉瘤 肾脂肪囊 医学 肾切除术 转移 肾静脉 粘液样脂肪肉瘤 软组织 肉瘤 病理 癌症 内科学
作者
Ashley N. Scheiderer,Armita Bahrami,Viraj A. Master,Adeboye O. Osunkoya
出处
期刊:International Journal of Surgical Pathology [SAGE]
卷期号:31 (7): 1179-1186
标识
DOI:10.1177/10668969221133356
摘要

A variety of primary malignant mesenchymal neoplasms can arise from the perinephric soft tissue and hilar vessels and potentially involve the kidney, mimicking primary renal tumors. A search was made at our institution for patients that underwent radical nephrectomy with associated perinephric or hilar sarcomas from 2010 to 2021. Twenty-six patients were identified. Mean patient age was 60 years (range: 34–83 years), with 16 (62%) females and 10 (38%) males. The mean tumor size was 21.6 cm (range: 8.1–36.5 cm). Among the perinephric/retroperitoneal sarcomas, 14/20 (70%) were dedifferentiated liposarcoma, 4/20 (20%) were well-differentiated liposarcoma, and 2/20 (10%) were leiomyosarcoma. There were 4 grade 1 (20%; all well-differentiated liposarcoma), 9 grade 2 (45%), and 7 grade 3 (35%) tumors. All 6 sarcomas arising from the renal vein/inferior vena cava were leiomyosarcoma: grade 2 in 1 (17%), grade 3 in 4 (67%), and ungraded (due to neoadjuvant therapy effect) in 1 (17%) patient. Four of the 26 (15%) tumors involved the ipsilateral kidney. All 4 tumors were grade 3 sarcomas. On follow-up, 8/26 (31%) patients developed local recurrence and/or metastasis. The mean time for recurrence was 22 months (range: 7–48 months). Two patients progressed with metastasis to the lungs, both of which were grade 3 leiomyosarcoma, and appeared 11 months after the initial diagnosis. Our data suggest that while local recurrence is prevalent with most subtypes of perinephric sarcomas, high-grade leiomyosarcoma has a distinct proclivity for distant metastasis, with the lungs being the most common site.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
希望天下0贩的0应助老肥采纳,获得10
1秒前
Morry完成签到,获得积分10
1秒前
笨DD完成签到 ,获得积分10
2秒前
zsqqqqq完成签到,获得积分10
2秒前
小白菜发布了新的文献求助30
3秒前
学以致用完成签到,获得积分10
4秒前
WangRui完成签到,获得积分10
4秒前
小美娴完成签到,获得积分10
4秒前
4秒前
李健的小迷弟应助风尚采纳,获得10
5秒前
aaa完成签到,获得积分10
5秒前
Mei完成签到,获得积分10
5秒前
onestepcloser完成签到 ,获得积分10
5秒前
慕青应助Jeremy采纳,获得10
6秒前
zhangyuheng完成签到,获得积分10
7秒前
斯文败类应助花痴的衬衫采纳,获得10
8秒前
哇哇哦wawao完成签到,获得积分10
9秒前
万能图书馆应助黄建雨采纳,获得10
9秒前
机智的凡英完成签到,获得积分20
10秒前
衣蝉完成签到 ,获得积分10
10秒前
丫丫发布了新的文献求助20
10秒前
10秒前
neurist完成签到,获得积分10
11秒前
照烧鸡腿完成签到,获得积分20
11秒前
唠叨的善若完成签到,获得积分10
11秒前
DNA甲基转移酶完成签到,获得积分10
11秒前
NexusExplorer应助科研通管家采纳,获得10
12秒前
membrane应助科研通管家采纳,获得10
12秒前
科研通AI2S应助福禄小金刚采纳,获得10
12秒前
Renhong应助科研通管家采纳,获得10
12秒前
CodeCraft应助科研通管家采纳,获得10
12秒前
JamesPei应助科研通管家采纳,获得10
12秒前
Renhong应助科研通管家采纳,获得10
12秒前
12秒前
Owen应助科研通管家采纳,获得10
12秒前
研友_VZG7GZ应助科研通管家采纳,获得10
12秒前
科研通AI2S应助科研通管家采纳,获得10
13秒前
CodeCraft应助科研通管家采纳,获得10
13秒前
大模型应助科研通管家采纳,获得20
13秒前
13秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Very-high-order BVD Schemes Using β-variable THINC Method 870
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
Fundamentals of Dispersed Multiphase Flows 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3253484
求助须知:如何正确求助?哪些是违规求助? 2896071
关于积分的说明 8289894
捐赠科研通 2564816
什么是DOI,文献DOI怎么找? 1392580
科研通“疑难数据库(出版商)”最低求助积分说明 652230
邀请新用户注册赠送积分活动 629559