生物
癌症研究
巨噬细胞极化
宫颈癌
恶性转化
组蛋白
巨噬细胞
免疫学
癌症
遗传学
基因
体外
作者
Chenlingzi Huang,Lujiadai Xue,Xinzi Lin,Yuan Shen,Xiaoyu Wang
标识
DOI:10.1089/dna.2024.0122
摘要
Cervical cancer (CC) is the most common cancer in women. This study aims to explore the molecular mechanism of lactate secreted by CC cells modulating macrophage polarization in CC via histone lactylation. Normal cervical epithelium (NCE), low-grade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion (HSIL), and cervical squamous cell carcinoma (CESC) were collected to assess H3K18la level and macrophage infiltration. Macrophages were incubated with SiHa cell-derived conditioned medium to detect M1 and M2 markers. NCE, HSIL, and CESC samples were used for ChIP-seq of H3K18la. Histone lactylation-dirven
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