适体
纳米材料
纳米技术
DNA
生物相容性材料
核酸
材料科学
干细胞
间充质干细胞
组织工程
生物物理学
化学
细胞生物学
生物
分子生物学
生物医学工程
遗传学
生物化学
医学
作者
Hongshu Li,Rui Li,Songlin He,Yu Wang,Wei-Wei Fang,Yufeng Jin,Rui Yang,Yin Liu,Qing Ye,Xi Peng
出处
期刊:Nano Letters
[American Chemical Society]
日期:2023-06-20
卷期号:23 (18): 8399-8405
标识
DOI:10.1021/acs.nanolett.3c01240
摘要
Stem cells possess exceptional proliferation and differentiation abilities, making them highly promising for targeted recruitment research in tissue engineering and other clinical applications. DNA is a naturally water-soluble, biocompatible, and highly editable material that is widely used in cell recruitment research. However, DNA nanomaterials face challenges, such as poor stability, complex synthesis processes, and demanding storage conditions, which limit their potential applications. In this study, we designed a highly stable DNA nanomaterial that embeds nucleic acid aptamers in the single strand region. This material has the ability to specifically bind, recruit, and capture human mesenchymal stem cells. The synthesis process involves rolling circle amplification and topological isomerization, and it can be stored for extended periods under varying temperatures and humidity conditions. This DNA material offers high specificity, ease of fabrication, simple preservation, and low cost, providing a novel approach to stem cell recruitment strategies.
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