Liver-adipose tissue crosstalk in non-alcoholic fatty liver disease: The emerging role of remnant cholesterol

We read with great interest the recent review by Lee et al. on the importance of adipose tissue dysfunction in the pathogenesis of non-alcoholic fatty liver disease (NAFLD).1 Metabolic inflexibility of adipose tissue, including white adipose tissue and brown adipose tissue (BAT), contributes to the systemic metabolic dysregulation in NAFLD and affects the pathophysiology of NAFLD through a range of mechanisms mediating liver-adipose tissue crosstalk.1 We highly endorse and appreciate the authors' adipocentric views on the onset and progression of NAFLD.